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2007 | 63 | 08 |

Tytuł artykułu

Effect of synthetic GnRH analogues on ovarian follicular growth dynamic and oestrus

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the present study was to evaluate the stimulating effect of synthetic GnRH analogues without the use of prostaglandins on ovarian follicular growth dynamic and oestrus. The study was made on 30, 3 to 9-year-old Lithuanian Black and White (LBW) and German Black and White (GBW) breed cows. The study was conducted in the Lithuanian Veterinary Academy practical training and research farm. Oestrus in 23 cows was stimulated using synthetic GnRH analogues Dalmarelin (Lecirelin) (Fatro S. p. A., Italy) and in 14 cows with the use of Depherelin® (Gonavet® 50, Veyx-Pharma GmbH, Germany). Dalmarelin (Lecirelin) induced oestrus in 100% of the stimulated cows, and Depherelin® (Gonavet® 50) induced oestrus in 92.9 % of stimulated cows. Following an injection of synthetic GnRH analogues, preparations Depherelin® and Dalmarelin, plasma progesterone concentration decreased, due to the ovulation of dominant follicle or onset of the new follicular wave. Cows stimulated with Dalmarelin had a faster follicular growth rate and bigger size of follicles at ovulation compared to Depherelin® and control group cows (p = 0.05). In the pregnancy trial that followed 45 days after artificial insemination, the highest percentage (43.5 %) of pregnant cows was determined in the group of cows stimulated with Dalmarelin.

Wydawca

-

Rocznik

Tom

63

Numer

08

Opis fizyczny

p.922-925,fig.,ref.

Twórcy

autor
  • Lithuanian Veterinary Academy, Tilzes st.18, LT-47181, Kaunas, Lithuania
autor

Bibliografia

  • 1.Bartolome J. A., Melendez P., Kelbert D., Swift K., McHale J., Hernandez J., Silvestre F., Risco C. A., Arteche A. C., Thatcher W. W., Archbald L. F.: Strategic use of gonadotrophin-releasing hormone (GnRH) to increase pregnancy rate and reduce pregnancy loss in lactating dairy cows subjected to synchronization of ovulation and timed insemination. Theriogenology 2005, 63, 1026-1037.
  • 2.Chenault J. R., Kratzer D. D., Rzepkowski R. A., Goodwin M. C.: LH and FSH response of Holstein heifers to fertirelin acetate, gonadorelin and buserelin. Theriogenology 1990, 34, 81-98.
  • 3.Doložel R., Čech S., Zajic J., Havliček V.: Oestrus Synchronization by PGF₂α and GnRH in Intervals according to Stage of Follicular Development at Time of Initial Treatment in Cows. Acta Veterinaria, Brno 2002, 71, 101-108.
  • 4.Doložel R., Novotny R., Čech S., Zajic J., Havliček V.: Effect of simultaneous administration of PGF₂α and GnRH on follicular development, oestrus and the timing of ovulation in cows. Acta Veterinaria, Brno 2000, 61, 289-296.
  • 5.Duchens M., Forsberg M., Edqvist L.-E., Gustafsson H., Rodriguez-Martinez H.: Effect of induced subrabasal progesterone levels around oestrus on plasma concentrations of progesterone, estradiol-17β and LH in heifers. Theriogenology 1994, 42, 1159-1169.
  • 6.Foster J. P., Lamming G. E., Peters A. R.: Short-term relationships between plasma LH and FSH and progesterone concentration in post-partum dairy cows and the effect of GnRH injection. J. Reprod. Fertil. 1980, 59, 321-327.
  • 7.Franco C. M.: Strategies to enhance fertility in dairy cattle during summer including use of cryopreservation of in vitro produced embryos. Doctoral diss., University of Florida 2006.
  • 8.Ginther O. J., Wiltbank M. C., Fricke P. M., Gibbons J. R., Kot K.: Selection of the dominant follicle in cattle. Biology Reprod. 1996, 55, 1187-1194.
  • 9.Hall J. B., Dee Whittier W., Myers J., Cline M., Cuddy D.: GnRH Based Estrus Synchronization Systems for Beef Cows. Virginia State, Virginia Cooperative Extension, Petersburg 2002, 1-6.
  • 10.Lemaster J. W., Yelich J. V., Kempfer J. R., Fullenwider J. K., Barnett C. L., Fanning M. D., Selph J. F.: Effectiveness of GnRH plus prostaglandin F₂α for estrus synchronization in cattle of Bos indicus breeding. J. Anim. Sci. 2001, 79, 309-316.
  • 11.López-Gatius F., Lopez-Bejar M., Fenech M., Hunter R. H.: Ovulation failure and double ovulation in dairy cattle: risk factors and effects. Theriogenology 2005, 63, 1298-1307.
  • 12.Murugavel K.: Reproductive performance of dairy cows following different estrous synchronization protocols. Doctoral diss., Universitat Autonoma de Barselona 2003.
  • 13.Noseir W. M. B.: Ovarian follicular activity and hormonal profile during estrous cycle in cows: the development of 2 versus 3 waves. Reprod. Biol. Endocrinol. 2003, 50, 1-6.
  • 14.Rettmer I., Stevenson J. S., Corah L. R.: Pregnancy rates in beef cattle after administering a GnRH agonist 11 to 14 days after insemination. J. Anim. Sci. 1992, 70, 7-12.
  • 15.Ryan D. P., Snijders S., Condon T., Grealy M., Sreenan J., O'Farrell K. J.: Endocrine and ovarian responses and pregnancy rates in dairy cows following the administration of a gonadotrophin releasing hormone analog at the time of artificial insemination or at mid-cycle post insemination. Anim. Reprod. Sci. 1994, 34, 179-191.
  • 16.Ryan M., Mihm M., Roche J. F.: Effect of GnRH given before or after dominance on gonadotropin response and the fate of that follicle wave in postpartum dairy cows. J. Reprod. Fertil. 1998, 21, 28 abstr.
  • 17.Sirois J., Fortune J. E.: Ovarian follicular dynamics during the oestrous cycle in heifers monitored by real-time ultrasonography. Biol. Reprod. 1988, 39, 308-317.
  • 18.Stevenson J. S., Phatak A. P., Rettmer I., Steward R. E.: Postinsemination administration of receptal: follicular dynamics, duration of cycle, hormonal responses, and pregnancy rates. J. Dairy Sci. 1993, 76, 2536-2547.
  • 19.Taponen J., Katila T., Rodriguez-Martinez H.: Induction of ovulation with gonadotropin - realising hormone during proestrus in cattle: influence on subsequent follicular growth and luteal function. Anim. Reprod. Sci. 1999, 55, 91-105.
  • 20.Thatcher W. W., Macmillan K. L., Hansen P. J., Drost M.: Concepts for regulation of corpus luteum function by the conceptus and ovarian follicles to improve fertility. Theriogenology 1989, 31, 149-164.
  • 21.Twagiramungu H., Guilbault L. A., Dufour J. J.: Synchronization of ovarian follicular waves with a gonadotropin-releasing hormone agonist to increase the precision of estrus in cattle: a review. J. Anim. Sci. 1995, 73, 3141-3151.
  • 22.Ullah G., Fuquay J. W., Keawkhong T., Clark B. L., Pogue D. E., Murphey E. J.: Effect of gonadotropin-releasing hormone at estrus on subsequent luteal function and fertility in lactating Holsteins during heat stress. J. Dairy Sci. 1996, 79, 1950-1953.
  • 23.Willard S., Gandy S., Bowers S., Graves K., Elias A., Whisnant C.: The effects of GnRH administration postinsemination on serum concentrations of progesterone and pregnancy rates in dairy cattle exposed to mild summer heat stress. Theriogenology 2003, 59, 1799-1810.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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