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1992 | 38 | 1-2 |

Tytuł artykułu

Wolne rodniki w inwazji pasozytniczej

Autorzy

Treść / Zawartość

Warianty tytułu

Języki publikacji

PL

Abstrakty

EN
Highly reactive oxygen species potentially represent a powerful effector mechanism against parasites. They are produced during normal cellular metabolism, especially by activated phagocytes. As can be seen from many studies protozoan and helminth parasites appear to have one or more anti-oxidant enzymes able to scavenge or quench the reactive free-radicals, and there is strong evidence that such enzymes may play crucial role in protecting against host response. Presented there review illustrates that methods to block anti-oxidant protection of parasites may be new field in the search for improved ways to inhibit parasitic survival.

Wydawca

-

Rocznik

Tom

38

Numer

1-2

Opis fizyczny

s.17-22, tab.,bibliogr.

Twórcy

autor
  • Instytut Doswiadczalnej PAN, ul.Pasteura 3, 02-093 Warszawa

Bibliografia

  • BABIOR B. M., KIPNES R. S., CURNUTTE J. L. 1973. Biological defense mechanisms, J. Clin. Invest. 52: 741-744.
  • CALLAHAN H. L., CROUCH R. K., JAMES E. R. 1988. Helminth anti-oxidant enzymes: a protective mechanism against host oxidants? Parasitol. Today 4: 218-225.
  • CLARK I. A., HUNT N. H. 1983. Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria. Infect. Immunol. 39: 1-6.
  • COWDEN W. B., LEWIS-HUGHES P. H., CLARK I. A. 1985. Protection against alloxan-induced diabetes in mice by the free-radical scavanger butylated hydroxyanisole. Biochem. Pharmacol. 34: 360-361.
  • DOCAMPO R., MORENO S. N. J. 1984. Free radical intermediates in antiparasitic action of drugs and phagocytic cells. In: W. A. PRYOR [Ed.] Free radicals in biology. Academic Press, New York: 243-288.
  • FAIRFIELD A. S., MESHNIK S. R., EATON J. W. 1983. Malaria parasites adopt host cell superoxide dismutase. Science 221: 764-766.
  • KAZURA J. W., MESHNIK S. R. 1984. Scavenger enzymes and resistance to oxygen-mediated damage to Trichinella spiralis. Mol. Biochem. Parasitol. 10: 1-10.
  • KETTERIDGE D. S. 1978. Lipopolysaccharide from Trypanosoma cruzi. Trans. R. Soc. Trop. Med. Hyg. 11: 101-102.
  • MCGREGOR I. A., GILLES H. M., WALTERS J. H., DAVIES A. H., PEARSON F. A. 1956. Effects on heavy and repeated malaria infections on Gambian infants and children. Brit. Med. J. 2: 686-692.
  • MOREL D. W., HESSLER J. R., CHISHOLM G. M. 1983. Low density lipoprotein toxicity induced by free radicals peroxidation of lipid. J. Lipid Res. 24: 1070-1076.
  • MURRAY H. W., MASUR H., KEITHLY J. S. 1982. Cell-mediated immune response in experimental visceral leishmaniasis J. Immunol. 129: 344-350.
  • NATHAN C. F., MURRAY H. W., WIEBE M. E., RUBIN B. Y. 1983. Identification of r-interferon as lymphokinine that activates human macrophage ox.idative metabolism and microbial activity. J. Exp. Med. 158: 670-689.
  • -., ROOT R. K. 1977. Hydrogen peroxide release mouse peritoneal macrophages. Ibid. 146: 1648-1662.
  • SEED J. R. 1980. The possible role of aromatic amino acid catabolites in the pathogenity of Trypanosoma brucei gambiense. In: H. Van den BOSSCHE [Ed.]. The host invader interplay. Elsevier North-Holland, Amsterdam: 273-283.
  • TILL G. O., JOHNSON K. J., KUNKEL R., WARD P. A. 1982. Intravascular activation of complement and acute lung injury. J. Clin. Inv. 69: 1126-1135.
  • URQUHART G. M. 1978. Seminar on trypanosomias. Trans. R. Soc. Trop. Med. Hyg. 72: 118-119.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-db834edf-1733-4406-aa46-4c528ec070be
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