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2010 | 62 | 2 |

Tytuł artykułu

Szczepy Acinetobacter baumannii oporne na karbapenemy

Warianty tytułu

EN
Carbapenem-resistant Acinetobacter baumannii strains

Języki publikacji

PL

Abstrakty

PL
Przeprowadzono analizę retrospektywną szczepów Acinetobacter baumannii opornych na imipenem i/lub meropenem izolowanych w latach 2007-2009 z materiału od chorych leczonych w Szpitalu Uniwersyteckim nr 1 im. dr. A. Jurasza w Bydgoszczy. W okresie objętym analizą od 113 chorych izolowano 166 szczepów A. baumannii o fenotypie oporności na karbapenemy. Odnotowano w kolejnych latach wzrost odsetka szczepów opornych na imipenem i spadek - szczepów opornych na meropenem.
EN
A. baumannii rods are opportunistic pathogens responsible generally for nosocomial infections. Resistance to carbapenems, observed among them, is a serious threat due to ability to be transmitted between bacterial species. The aim of our study was to evaluate the frequency of isolation and susceptibility to antibiotics of resistant to imipenem and/or meropenem A. baumannii strains isolated between 2007 and 2009 from patients of University Hospital of dr A. Jurasz Collegium Medicum of L. Rydygier in Bydgoszcz Nicolaus Copernicus University in Toruń. Study shows increasing frequency of isolation that type of strains from 4 in 2007 to 95 in 2008 and 67 in 2009. Percentage of imipenem-resistant isolates raised to 27,6% in 2008 and 31,0% in 2009. Meropenem-resistant A. baumannii isolates frequency changed from 2,1% in 2007 to 31,2% and 34,6%, in 2008 and 2009, respectively. The majority of strains were obtained from patients of the Intensive Care Units and surgery clinics. Examined^, baumannii strains were generally isolated from bronchoalveolar lavage (25,3%) and wound (18,1%) or throat (12,0%) swabs samples. The isolates demonstrated full resistance to norfloxacin, ciprofloxacin, and chloramphenicol. Ampicillin/sulbactam (24,8%), tobramycin (8,1%) and Colistin (1,5%) presented the highest in vitro activity against isolated strains.

Wydawca

-

Rocznik

Tom

62

Numer

2

Opis fizyczny

s.119-126,rys.,tab.,bibliogr.

Twórcy

autor
  • Collegium Medicum im.L.Rydygiera w Bydgoszczy, Uniwersytet Mikolaja Kopernika w Toruniu, ul.M.Curie-Sklodowskiej 9, 85-094 Bydgoszcz

Bibliografia

  • 1. Afzal-Shah M, Livermore DM. Worldwide emergence of carbapenem-resistant Acinetobacter spp. J Antimicrob Chemother. 1998; 41: 576-7
  • 2. Boo TW, Walsh F, Crowley В. Molecular characterization of carbapenem-resistant Acinetobacter species in an Irish university hospital: predominance of Acinetobacter genomic species 3. J Med Microbiol. 2009; 58: 209-16
  • 3. Bush K. Metallo-beta-lactamases: a class apart. Clin Infect Dis. 1998; 27 Suppl 1: 48-53
  • 4. Cisneros JM, Rodriguez-Baño J. Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment. Clin Microbiol Infect. 2002; 8: 687-93
  • 5. Clinical and Laboratory Standards Institute. Perfomance standards for antimicrobial susceptibility testing. Eighteenth informational supplement (M100-S18). CLSI Wayne, Pa 2008
  • 6. Dalla-Costa LM, Coelho JM, Souza HA i inni. Outbreak of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 enzyme in Curitiba, Brazil. J Clin Microbiol. 2003 ; 41: 3403-6
  • 7. Dzierżanowska D. Patogeny zakażeń szpitalnych. W: Zakażenia szpitalne. Red. D. Dzierżanowska, α-medica press, Bielsko-Biała. 2007, 38-59
  • 8. Gniadkowski M, Żabicka D, Hryniewicz W. Rekomendacje doboru testów do oznaczania wrażliwości bakterii na antybiotyki i chemioterapeutyki 2009. Oznaczanie wrażliwości pałeczek Gram-ujemnych.
  • 9. Gospodarek E, Ziółkowski G. Antybiotykooporne szczepy Acinetobacter baumannii występujące w Polsce. Przegl. Epidemiol. 2000; 54: 88-96
  • 10. Manuel RJ, Shin GY, Farrag N, Holliman R. Endemic carbapenem-resistant Acinetobacter baumannii in a London hospital. J Antimicrob Chemother. 2003; 52: 141-2
  • 11. Naas T, Levy M, Hirschauer C i inni. Outbreak of carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-23 in a tertiary care hospital of Papeete, French Polynesia. J Clin Microbiol. 2005; 43: 4826-9
  • 12. Niumsup PR, Boonkerd N, Tansawai U, Tiloklurs M. Carbapenem-resistant Acinetobacter baumannii producing OXA-23 in Thailand. Jpn J Infect Dis. 2009; 62: 152-4
  • 13. Oliveira MS, Prado GV, Costa SF i inni. Ampicillin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp. J Antimicrob Chemother. 2008; 61: 1369-75
  • 14. Poirel L, Nordmann P. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol Infect. 2006; 12: 826-36
  • 15. Qi C, Malczynski M, Parker M, Scheetz MH. Characterization of genetic diversity of carbapenem- resistant Acinetobacter baumannii clinical strains collected from 2004 to 2007. J Clin Microbiol. 2008; 46: 1106-9
  • 16. Quale J, Bratu S, Landman D, Heddurshetti R. Molecular epidemiology and mechanisms of carbapenem resistance in Acinetobacter baumannii endemic in New York City. Clin Infect Dis. 2003; 37: 214-20
  • 17. Tsakris A, Tsioni C, Pournaras S i inni. Spread of low-level carbapenem-resistant Acinetobacter baumannii clones in a tertiary care Greek hospital. J Antimicrob Chemother. 2003; 52: 1046-7
  • 18. Valenzuela JK, Thomas L, Partridge SR i inni. Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii. J Clin Microbiol. 2007; 45: 453-60
  • 19. Wang H, Guo P, Sun H i inni. Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Antimicrob Agents Chemother. 2007; 51: 4022-8
  • 20. Wróblewska MM, Towner KJ, Marchel H, Łuczak M. Emergence and spread of carbapenem-resistant strains of Acinetobacter baumannii in a tertiary-care hospital in Poland. Clin Microbiol Infect. 2007; 13: 490-6

Typ dokumentu

Bibliografia

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Identyfikator YADDA

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