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2007 | 51 | 1 |

Tytuł artykułu

Cardiopulmonary effects of acepromazine-ketamine administration in the sheep

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The effects of acepromazine-ketamine on the heart rate, arterial blood pressure, respiratory rate, blood gases, arterial blood pH, and temperature were investigated in six healthy sheep. Ketamine (11 mg/kg i.v.) was given 15 min after administration of acepromazine (0.05 mg/kg i.m.) A catheter was placed in the carotid artery for arterial blood sampling and recording of mean arterial blood pressure. All parameters were evaluated before the administration of acepromazine and at 5, 15, 30, 45, and 60 min following the injection of ketamine. The arterial blood pressure was recorded in 30 s after the injection of ketamine as well. The heart rate decreased significantly at minutes 15, 30, 45, and 60. The mean arterial blood pressure declined significantly at 30 s and 45 min. The mean respiratory rate decreased significantly at 45 and 60 min. PaO₂ decreased significantly at 5, 15, and 45 min, and PaCO₂ increased at 5 min. The pH values decreased significantly at 5, 15, and 30 min. The body temperature decreased significantly at all points in time. The data showed that the combination of acepromazine-ketamine caused an inhibition of the cardiovascular system. This combination is responsible for little distributed ventilation, decreased PaO₂, increased PaCO₂, decreased pH values, and a declined in body temperature in the anaesthesia period in sheep.

Wydawca

-

Rocznik

Tom

51

Numer

1

Opis fizyczny

p.93-96,ref.

Twórcy

autor
  • Shahid Chamran University, 61355-145 Ahvaz, Iran
autor

Bibliografia

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  • 2. Colby E.D., Sanford T.D.: Blood pressure and heart and respiratory rates of cats under ketamine/xylazine, ketamine/acepromazine anesthesia. Feline Pract 1981, 11, 19-24.
  • 3. Farver T.B., Haskins S.C., Patz J.D.: Cardiopulmonary effects of acepromazine and of the" subsequent administration of ketamine in the dog. Am J Vet Res 1986, 47, 631-635.
  • 4. Hall L.W., Clark K.W., Trim C.M.: Veterinary Anesthesia. 10th ed. W.B. Saunder's Co. London, 2001, pp. 76-79, 128-129.
  • 5. Hobbs B.A., Rolhall T.G., Sprenkel T.L., Anthony K.L.: Comparison of several combinations for anesthesia in rabbits. Am J Vet Res 1991, 52, 669-674.
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  • 8. Lopez K.R., Gibbs P.H., Reed D.S.: A comparison of body temperature changes due to the administration of ketamine-acepromazine and tiletamine-zolazepam anesthetics in Cynomolgu macaques. Contemp Top Lab Anim Sci 2002, 41, 47-50.
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  • 12. Newell S.M., Ko J.C., Ginn P.E., Heaton-Jones T.G., Hyatt D.A., Cardwell A.L., Mauragis D.F., Harrison J.M.: Effects of three sedative protocols on glomerular filtration rate in clinically normal dogs. Am J Vet Res 1997, 58, 446-450.
  • 13. Saberi Afshar F., Baniadam A., Marashipour S.P.: Effect of xylazine-ketamine on arterial blood pressure, arterial blood pH, blood gases, rectal temperature, heart and respiratory rates in sheep. Bull Vet Inst Pulawy 2005, 49, 481-484.
  • 14. Sanford T.D., Colby E.D.: Feline anesthesia induced by ketamine/acepromazine and ketamine/xylazine. Feline Pract 1982, 12, 16-24.
  • 15. Sawyer D.C.: Injectable anesthetics. Appl Anim Behav Sci 1998, 59, 171-178.
  • 16. Taylor P.M.: Anaesthesia in sheep and goats. In Pract 1991, 13, 31-36.
  • 17. Thurmon J.C., Kumar A., Cawley A.J.: Changes in the acid base status of sheep anaesthetized with a combination of atropine sulfate acepromazine and ketamine hydrochloride. Aust Vet J 1975, 51, 484-482.
  • 18. Thurmon J.C., Kumar A., Link R.P.: Evaluation of ketamine hydrochloride as an anesthetic in sheep. J Am Vet Med Assoc 1973, 162, 293-297.
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  • 20. Verstegen J., Fargetton X., Donnay I., Ectors F.: An evaluation of medetomidine-ketamine and other drug combinations for anesthesia in cats. Vet Rec 1991, 128, 32-35.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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