Effect of acute exposure to cadmium on the expression of calcitonin gene-related peptide [CGRP], calcitonin [CT], somatostatin [SST] and synaptophysin [SYN] in the C cells of the rat thyroid - a preliminary study

• Autorzy: Czykier E , Moniuszko-Jakoniuk J. , Sawicki B.
• Języki publikacji: EN

Abstrakty

EN

The aim of the present study was to determine to what degree acute exposure to cadmium affects the expression of CGRP, CT, SST and SYN in the C cells of the rat thyroid. Animals from 7 experimental groups received CdCl₂ iv. in doses of 3.5, 3, 2.5, 2, 1.5, 1 and 0.5 mg/kg b.w. respectively, while the control animals were given 0.9% NaCl iv. 24 hours after the iv. administration of CdCl₂, a correlation was found between a single dose of cadmium and the intensity of the immunocytochemical reactions for CGRP, CT, SST and SYN in C cells of the rat thyroid when compared to the control. The weakest immunocytochemical reactions were noted in C cells of the thyroid of rats from Groups I and II, their intensity gradually increasing in Groups III, IV and V in comparison to the control. The reaction intensity in animals of Groups VI and VII resembled those of the control.

Słowa kluczowe

EN

synaptophysin; calcitonin; C cell; thyroid gland; cadmium intoxication; thyroid; rat; somatostatin

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2004
• Tom: 63
• Numer: 2
• Opis fizyczny: p.217-219,fig.,ref.

Twórcy

autor

Czykier E

• Medical University, Kilinskiego 1, 15-089 Bialystok, Poland

autor

Moniuszko-Jakoniuk J.

autor

Sawicki B.

Bibliografia

• 1. Osius N, Karmaus W, Kruse H, Witten J (1999) Exposure to polychlorinated biphenyls and levels of thyroid hormones in children. Environ Health Perspect, 107: 843–849.
• 2. Gupta P, Kar A (1998) Role of ascorbic acid in cadmium-induced thyroid dysfunction and lipid peroxidation. J Appl Toxicol, 18: 317–320.
• 3. Pavia Jr MA, Noli MI, Hagmuuller K, Zaninovich AA (1997) Evidence suggesting that cadmium induces a non-thyroid illness syndrome in the rat. J Endocrinol, 154: 113–117.
• 4. Piłat-Marcinkiewicz B, Sawicki B, Brzóska M, Zabel M (2001) Preliminary immunohistochemical study of C cells of the thyroid and endocrine cells of the parathyroid glands in rats after prolonged exposure to cadmium. Folia Histochem Cytobiol, 39: 191–192.