EN
Reproductive losses in fur animal farms in Poland caused by parvovirus infections indicated the necessity to develop effective immunopreparates. During 1993-1994 experimental vaccines for foxes and minks were prepared. They contained inactivated and attenuated parvoviruses of cats (strain FPV-FA1) and minks (strain MEV-143). Viruses were propagated in a permanent cell line of feline lungs. Safety and immunological activity of experimental vaccines, as well as commercial vaccines used for dogs and cats in Poland, were estimated. Additionally, vaccines containing inactivated mink enteritis virus used in Scandinavia for the immunization of foxes and minks were included in the experiment. The activity of vaccines was estimated on the basis of parvoviral antibody levels in vaccinated animals. An experimental vaccine containing strain MEV-143 was the most effective, even 1/5-th of the dose induced specific antibodies. Comparable results were obtained when reference vaccines containing inactivated mink enteritis virus were used. Full protection in vaccinated foxes was developed 28 days after vaccination. The obtained results were the basis for large scale field experiments carried out in Poland during 1994/95.