EN
Powdered fire-extinguisher agents Pollenit F (LB-3) and Totalit Super 80 were tested. The agents have not been tested yet for their possible harmful effects. Both contain silica and talc, hence may be suspected of fibrogenic properties. Male Wistar rats were used in the tests. The animals received intratracheally 0.5 ml of aqueous 0.9% NaCl solution containing 50 mg Pollenit F and 10 mg Totalit Super 80. The following indices were evaluated after 1.5, 3 and 6 months: body weight, wet and dry lung weight, and total lung hydroxyproline content. In our experiment the test agents did not significantly affect body or lung weight, but caused a slight increase of hydroxyproline content. Our results point to a slight fibrogenic and negligible biological activity of Pollenit F and Totalit Super 80.