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2008 | 17 | 6 |

Tytuł artykułu

Reproduction parameters in low dose chronic exposure with heavy metals in rats

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to evaluate the effects of low-dose chronic lead, mercury and cadmium expo­sure on the reproductive potency of Wistar rats and on their progeny. The number of litters and the number of newborns in rats exposed to Pb and Hg were significantly higher compared to controls, whereas between Cd exposure group and controls there was almost no difference. In contrast, the survival rate of the weanlings decreased in the order Cd>Pb>Hg and in all exposed groups was higher than in controls. The results suggest that an increase in reproduction rate early after intoxication onset may disclose certain reactive adaptation mechanisms. The number of weanlings appears to be a sensitive marker in reprotoxicity tests.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

17

Numer

6

Opis fizyczny

p.911-915,fig.,ref.

Twórcy

autor
  • University of P.J. Safarik, Tr.SNP 1, 040 66 Kosice, Slovak Republic
autor
autor
autor
autor

Bibliografia

  • 1. NADADUR S.S., MILLER C.A., HOPKE K.H., GORDON T., VEDAL S., VANDEN-BERG J.J., COSTA D.L. The com­plexities of air pollution: the need for an integrated re-search and regulatory perspective. Toxicol. Sci. 100, 318, 2007.
  • 2. ROMIEU I., CASTRO-GINER F., KUNZLI N., SUNYER J. Air pollution, oxidative stress and dietary supplementa­tion: a review. Eur. Respir. J. 31, 179, 2008.
  • 3. BARANOWSKA I., SROGI K., WLOCHOWICZ A., SZCZEPANIK K. Determination of heavy metal contents in samples of medicinal herbs. Polish J. Environ. Stud. 11, 467, 2002.
  • 4. SHARPLEY A. Soil and water contamination: from molec­ular to catchment scale. J. Environ. Qual. 36, 607, 2007.
  • 5. NECULITA C.-A., ZAGURY G.J., BUSSIÉRE B. Passive treatment of acid mine drain-age in bioreactors using sul­phate-reducing bacteria: critical review and research needs. J. Environ. Qual. 36, 1, 2007.
  • 6. HARTWIG A., ASMUSS M., EHLEBEN I., HERZER U., KOSTELAC D., PELZER A., SCHWERDTLE T., BÜRKLE A. Interference by toxic metal ions with DANN repair processes and cell cycle control: molecular mecha­nisms. Environ. Health Perspect. 110, 797, 2002.
  • 7. LEONARD S.S., HARRIS G.K., SHI X. Serial-reviews: redox-active metal ions, reactive oxygen species, and apop- tosis. Free Radic. Biol. Med. 37, 1921, 2004.
  • 8. VALKO M., MORRIS H., CRONIN M.T.D. Metals, toxici­ty and oxidative stress. Curr. Med. Chem., 12, 1161, 2005.
  • 9. VALKO M., RHODES C.J., MONCOL J., IZAKOVIC M., MAZUR M. Free radicals, metals and antioxidants in oxida- tive stress-induced cancer. Chem.-Biol. Inter., 160, 1, 2006.
  • 10. BRODKIN E., COPES R., MATTMAN A., KENNEDY J., KLING R., YASSI A. Lead and mercury exposures: inter­pretation and action. Can. Med. Assoc. J. 176, 59, 2007.
  • 11. SOTOU S., YAMAMOTO K., SENDOTA H., SUGIYAMA M. Toxicity, fertility, teratogenicity, and dominant lethal tests in rats administered cadmium subchronically. II. Fertility, teratogenicity, and dominant lethal tests. Ecotoxicol. Environ. Saf. 4, 51, 1980.
  • 12. PAKSY K., VARGA B., LAZAR P. Effect of cadmium on female fertility, pregnancy and postnatal development in the rat. Acta Physiol. Hung. 84, 119, 1996.
  • 13. SOKOL R.Z. The hypothalamic-pituitary-gonadal axis as a target for toxicants. In: SIPES I.C., MCQUEEN C.A., GANDOLFI A.J. (Eds.): Comprehensive Toxicology. Vol. 10. Elsevier Science, Oxford, pp. 87-98, 1997.
  • 14. LAFUENTE A., MÁRQUEZ N., PÉREZ-LORENZO M., PAZO D., ESQUIFINO A.I. Cadmium effects on hypothal- amic-pituitary-testicular axis in male rats. Exp. Biol. Med. 226, 605, 2001.
  • 15. SATO M., KONDOH M. Recent studies on metallothionein:protection against toxicity of heavy metals and oxygen free radicals. Tohoku J. Exp. Med. 196, 9, 2002.
  • 16. KAMIŃSKI P., KURHALYUK N., SZADY-GRAD M. Heavy metal-induced oxidative stress and changes in physi­ological process of free radicals in the blood of white stork (Ciconia ciconia) chicks in polluted areas. Polish J. Environ. Stud. 16, 555, 2007.
  • 17. SINGH V.K., MISHRA K.P., RANI R., YADAV V.S., AWASTHI S.K., GARG S.K. Immunomodulation by lead. Immunol. Res. 28, 151, 2003.
  • 18. BISER J.A., VOGEL L.A., BERGER J., HJELLE B., LOEW S.S. Effects of heavy metals on immunocompetence of white-footed mice (Peromyscus leucopus). J. Wildlife Dis. 40, 173, 2004.
  • 19. WAALKES M.P. Cadmium carcinogenesis. Mutat. Res. 533, 107, 2003.
  • 20. WAISBERG M., JOSEPH P., HALE B., BEYERSMANN D. Molecular and cellular mechanisms of cadmium carcino­genesis. Toxicology, 192, 95, 2003.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-d743dbab-b997-4011-bf24-f3a65dc551fa
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