The effects of plant extracts of Medicago sativa and Trigonella foenum-graecum on postprandial glucose levels in type 2 diabetic rats

• Autorzy: Winiarska H , Dworacka M. , Borowska M. , Bobkiewicz-Kozlowska T. , Gorecki P. , Mscisz A. , Mrozikiewicz P.M.

Warianty tytułu

PL

Wplyw wyciagow roslinnych Medicago sativa i Trigonella foenum-graecum na poposilkowe stezenie glukozy - badania na zwierzecym modelu cukrzycy typu 2

• Języki publikacji: EN

Abstrakty

EN

The main purpose of this study was to determine if fenugreek (Trigonella foenum graecum L.) seeds extract (FSE ) and lucerne (Medicago sativa L.) extract (LDE) modulate post-challenge carbohydrate metabolism in type 2 diabetes animal model. Type 2 diabetes was induced in the Wistar rat neonates by intraperitoneal administration of streptozotocin. Experimental animals (60) were divided into following groups: normal rats treated with FSE or LDE, diabetic rats treated with FSE or LDE or glibenclamide or vehicle and given orally examined substances for 4 weeks. Glycaemia was controlled prior to the administration of test substances and at time points of 2 h and 4 h, thereafter at 1st, 7th and the last day of experiment. Insulin serum concentration was measured at time 0 at the same days. The present study demonstrates the ability of FSE and LDE to decrease postprandial glycaemia in type 2 diabetic and non-diabetic rats. It seems that this effect mediated by enhancing insulin secretion is related only for LDE-treatment and observed only in n5-STZ rats.

PL

Celem pracy było zbadanie wpływu wyciągów z nasion kozierdaki (Trigonella foenum graecum L., FSE ) oraz ziela lucerny (Medicago sativa L., LDE) na poposiłkową glikemię u szczurów z cukrzycą typu 2. Typ 2 cukrzycy (n5-STZ) indukowano u noworodków szczurzych poprzez dootrzewnowe podanie streptozotocyny. Badanie przeprowadzono, podając dożołądkowo wyciągi roślinne (FSE lub LDE) oraz substancje kontrolne (glibenklamid lub vehiculum) przez 4 tygodnie zdrowym zwierzętom oraz szczurom z cukrzycą typu 2. Stężenie glukozy badano przed (na czczo) oraz po podaniu badanych substancji (2 i 4 godz. po podaniu) w 1., 7. i 28. dniu doświadczenia. W tych samych dniach badano także stężenie insuliny na czczo. Wykazano, że stosowanie wyciągu z nasion kozieradki oraz wyciągu z ziela lucerny jest związane z istotnym obniżeniem glikemii poposiłkowej w badanych grupach zwierząt zarówno z cukrzycą typu 2, jak i zdrowych. Wydaje się, iż efekt ten jest związany ze zwiększeniem sekrecji insuliny wyłącznie w odniesieniu do wyciągu z ziela lucerny.

Słowa kluczowe

EN

medicinal plant; plant extract; lucerne; Medicago sativa; diabetes type 2; Trigonella foenum-graecum; fenugreek; rat; glycaemia zob.glycemia; postprandial glycemia; diabetes

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2007
• Tom: 53
• Numer: 4
• Opis fizyczny: p.34-44,fig.,ref.

Twórcy

autor

Winiarska H

• University of Medical Sciences, Rokietnicka 5a, 60-806 Poznan, Poland

autor

Dworacka M.

autor

Borowska M.

autor

Bobkiewicz-Kozlowska T.

autor

Gorecki P.

autor

Mscisz A.

autor

Mrozikiewicz P.M.

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