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1994 | 40 | 2 |

Tytuł artykułu

Wplyw cyklosporyny A na przebieg miesniowej fazy wlosnicy u myszy

Treść / Zawartość

Warianty tytułu

Języki publikacji

PL

Abstrakty

EN
The authors tried to determine the role of TH lymphocytes in the course of muscular trichinellosis in mice. The investigations were carried out on the CFW mice infected with 200 Trichinella spiralis larvae and treated with Cyclosporine A to suppresse TH1 lymphocytes. In animals treated with the drug more numerous cells inside the larval capsules and more numerous granulomas compared to control were seen. At the same time the mean number of larvae was lower (69,2%) than in control. The results show that TH1 lymphocytes do not play the significant role in the destruction of muscular larvae. This is the first conclusion and requires of course futher investigations.

Wydawca

-

Rocznik

Tom

40

Numer

2

Opis fizyczny

s.133-140, rys.,bibliogr.

Twórcy

autor
  • Instytut Parazytologii PAN, Wroclaw
autor

Bibliografia

  • BOLAS-FERNANDEZ F., GRENCIS R. K., WAKELIN D. 1988. Cyclosporin A and Trichinella spiralis: anthelmintic effects in immunosuppressed mice. Parasite Immunology 10: 111-116.
  • CABAJ W. 1990. The effect of cyclosporin A on the course of infection by Trichinella pseudospiralis or Nematospiroides dubius on C3H strain mice. Acta Parasitol. Pol. 35: 241-253.
  • CHAPPELL L. H., WARTLING J. M., HURD H. 1989. Action of Cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo. Parasitology 98: 291-299.
  • DAVIS S. W., HAMMERBERG B. 1990. Effect of depletion of L3T4⁺ cells on resistance to early primary infection of mice with Taenia taeniaeformis. J. Parasitology 20: 595-601.
  • FIDELIUS R. K., FERGUSON R. M., WIDMER M. B., WEE SIEW-LIN, BACH F. H., OROSZ C. G. 1982. Effect of cyclosporin A on murine and human T helper cell clones. Transplantation 34: 308-311.
  • FOXWELL B. M., RUFFEL B. 1990. The mechanisms of action of cyclosporine. Cardiol-Clin. 8: 107-117.
  • GORRELL M. D., WILLIS G., BRANDON M. R., LOSCELLES A. K. 1988. Lymphocyte phenotypes in the intestinal mucosa of sheep infected with Trichostrongylus colubriformis. Clin. Exp. Immunology 72: 274-279.
  • GRENCIS R. K., BOLAS-FERNANDEZ F., WAKELIN D. 1988. Analysis of cellular immune response during intestinal infection by Trichinella spiralis in mice treated with Cyclosporin A. Program and abstracts. 7th Int Conf. Trichinell. 71. Alicante (Spain).
  • HEROLD K. C. LANCHI D. W., MOLDWIN R. L., FITH F. w. 1986. Immunosuppressive effects of Cyclosporine A on cloned T cells. J. Immunology 136: 1315-1321.
  • HEYWORTH M. F. 1989. Intestinal IgA responses to Giardia muris in mice depleted of helper T lymphocytes and in immunocompetent mice. J. Parasitology 75: 246-251.
  • - ., CARLSON J. R., ERMAK T. H. 1987. Clearance of Giardia muris infection requires helper/inducer T. lymphocytes. J. Exp. Med. 165: 1743-1748.
  • HOUSE R., DEAN J. H. 1988. Trypanosoma musculi: characterization of the T-lymphocyte dependency of immunity by selective immunomodulation of the mouse, Mus musculus. Exp. Parasitology 67: 104-115.
  • KARMAŃSKA K., MICHALSKA Z., MIELCZAREK J., ŚLASKA B. 1987. Dynamika zmian immunopatologicznych w mięśniowej fazie włośnicy. Wiad. Parazytol. 33: 509-515.
  • KATONA I. M., URBAN I. F. Jr, FINKELMAN F. D. 1988. The role of L3T4⁺ and Lyt-2⁺ cells in the IgE response and immunity to Nippostrongylus brasiliensis. J. Immunology 140: 3206-3211.
  • KELLY E. A. B., COLLEY D. G. 1988. In vivo selects of monoclonal anti- L3T4 antibody on immune responsiveness of mice infected with Schistosoma mansoni. Ibid. 140: 2737-2745.
  • KORENAGA M., W ANG C. H. 1989. Intestinal immunity to Trichinella spiralis is a property of OX22⁻ OX8⁻ - T-helper cells that are generated in the intestine. Immunology 66: 588-594.
  • KOZAR Z., KOZAR M. 1972. Diagnostyka chorób pasożytniczych człowieka. Warszawa, PZWL.
  • LANE PETTER W., PEARSON A. E. G. 1971. The laboratory Animal-Principles and Practice. Academic Press, London - New York.
  • LEIRO J., SANTAMARINA M. T., SERNANDEZ L., SANMARTIN M. L., UBEIRA F. M. 1989. The effect of cyclosporine A on murine trichinellosis. Parasitol. Res. 75: 330-332.
  • LETONJA T., HAMMERBERG C., DAVIS S., HAMMERBERG B. 1988. Taenia taeniaeformis: cellular reconstruction of athymic mice and role of L3T4⁺ helper T lymphocytes in the early infection. J. Parasitology 74: 985-992.
  • MUELLER J., BRUN DEL RE G., BUERKI H., KELLER H., HESS M., COTIER H. 1975. Nonspecific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes. Europ. J. Immunology 5: 270-274.
  • NILSON L. A., LINDBLAD R., OLLING S., OUCHERLONY O. 1985. The effect of cyclosporin A on the course of murine infection by Schistosoma mansoni. Parasite Immunology 7: 19-27.
  • PEREIRA G. M., MILLER J. F., SHEVACH E. M. 1990. Mechanism of action of cyclosporine A in vivo. II. T cell priming in vivo to alloantigen can be mediated by an II-2-independent cyclosporine A - resistant pathway. J. Immunol. 144: 2109-2116.
  • PHILLIPS S. M„ WALKER D., ABDEL-HAFEZ S. K„ LINEITE G. P., DOUGHTY B. L., PERRIN P. J., FATHELBAB N. 1987. The immune response to Schistosoma mansoni infections in inbred rats. VI. Regulation by T cell subpopulations. Ibid. 139: 2781-2787.
  • THOMSON A. W., SMITH S. W. G., CHAPPELL L. H. 1986. Cyclosporin A: immune suppressant and anti-parasitic agent. Parasitology Today 2: 288-290.
  • TOSHIBITO H., HIROSHI N., HIROSHI T. 1988. Effect of Cyclosporin on immune response in the rat gut. Int. J. Immunopathology 10 (Supp. 1): 111.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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