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2010 | 54 | 1 |

Tytuł artykułu

Apoptotic index and histological assessment of renal tubular epithelial cells during anthracycline-induced apoptosis. Influence of time

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The presented study describes renal tubular epithelial cells morphology in rats during adriamycin therapy. It was demonstrated that one dose of the compound can induce increasing-with time-apoptosis in the cells. A statistically-significant increase in the number of apoptotic cells was observed in experimental groups compared to controls. The highest percentage of apoptotic cells was found in rats 7 weeks after adriamycin administration. The number of apoptotic cells in these animals was statistically significantly higher than that in the rats 4 weeks after adriamycin administration.

Wydawca

-

Rocznik

Tom

54

Numer

1

Opis fizyczny

p.55-58,fig.,ref.

Twórcy

autor
  • Medical University of Lublin, 20-080 Lublin, Poland
autor

Bibliografia

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  • 2. Daugas E., Nochy D., Ravagnan L., Loeffler M., Susin S.A., Zamzami N., Kroemer G.: Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Left 2000, 476, 118-123.
  • 3. Drzewoski J., Robak T.: Clinical pharmacology of antineoplastic drugs. Nauka, Warszawa, 1991.
  • 4. Grzanka D., Domaniewski J., Grzanka A.: Effect of doxorubicin on actin reorganization in Chinese hamster ovary cells. Neoplasma 2005, 52, 46-51.
  • 5. Guo Y., Srinivasula S.M., Druilhe A., Fernandes- Alnemri T., Alnemri E.S.: Caspase 2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem 2002, 277, 13430-13437.
  • 6. Hickman J.A.: Apoptosis and chemotherapy resistance. Eur J Cancer 1996, 32A, 921-926.
  • 7. Lockshin R.A., Zakeri Z.: Apoptosis autophagy and more. Int J Biochem Cell Biol 2004, 36, 2405-2419.
  • 8. Lockshin R.A., Zakeri Z.: Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol 2002, 7, 545-550.
  • 9. Maslińska D.: Programmed cell death (apoptosis) during inflamation. Nowa Med Reumatol IV 1999, 12, 34-41.
  • 10. Motyl T.: Regulation of apoptosis: involvement of Bcl-2 related proteins. Reprod Nutr Dev 1999, 39, 49-59.
  • 11. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B., Yuan J.P.: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxity by amyloid-B. Nature 2000, 403, 98-103.
  • 12. Raff M.: Cell suicide and beginners. Nature 1998, 396, 119-122.
  • 13. Reed J.C.: Dysregulation of apoptosis in cancer. J Clin Oncol 1999, 17, 2941-2953.
  • 14. Skomra D., Chibowski D.: Assessment of Daunorubicin nephrotoxicity and effect of tocopherol and acsorbic acid on lesions induced in rat's kidneys. Part I. Histological, histochemical and biochemical studies. Ann Univ Mariae Curie-Sklodowska 1993, 98, 181-189.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-d5154787-63e1-4108-81a5-ca2598c6ea04
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