Homozygote for mutation c.1204 plus 1G A of the ARSA gene presents with a late-infantile from of metachromatic leukodystrophy and rare MRI white matter lesion type

• Autorzy: Lugowska A , Szymanska K. , Kmiec T. , Tarczynska I. , Czartoryska B. , Tylki-Szymanska A. , Jurkiewicz E.
• Języki publikacji: EN

Abstrakty

EN

The metachromatic leukodystrophy (MLD) - causing mutation c. 1204 + 1G > A damages an intron-exon splice site recognition sequence. This results in a complete loss of enzymatic activity of arylsulfatase A (ARSA) protein molecules. We have found a late-infantile type MLD-patient to be homozygous for this mutation, which was not reported earlier, but is consistent with previous suggestions. Interestingly, the cerebral magnetic resonance imaging (MRI) in this patient displayed linear or punctuate structures radiating in the demyelinated white matter, which resembled the patterns described in Pelizaeus-Merzbacher disease. It should be emphasised that whenever a cerebral MRI demonstrates the 'tigroid' or 'leopard-skin' demyelination pattern not only Pelizaeus-Merzbacher disease, but also metachromatic leukodystrophy diagnosis should be considered; this suggests the necessity of ARSA activity estimations in patients with such specific MRI patterns.

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2005
• Tom: 46
• Numer: 3
• Opis fizyczny: p.337-339,fig.,ref.

Twórcy

autor

Lugowska A

• Institute of Psychiatry and Neurology, Al.Sobieskiego 9, 02-957 Warsaw, Poland

autor

Szymanska K.

autor

Kmiec T.

autor

Tarczynska I.

autor

Czartoryska B.

autor

Tylki-Szymanska A.

autor

Jurkiewicz E.

Bibliografia

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