Histopathological and immunohistochemical examinations, and changes in proliferation activity of the uterus in bitches following zearalenon micotoxicosis

• Autorzy: Gajecka M. , Janowski T. , Jakimiuk E. , Polak M. , Podhalicz-Dziegielewska M. , Rotkiewicz T. , Otrocka-Domagala I. , Obremski K. , Zielonka L. , Gajecki M.
• Języki publikacji: EN

Abstrakty

EN

The research was aimed at determining the impact of the experimental oral administration of zearalenon on the uterus in bitches. The study was carried out on 9 sexually mature 1 to 3 year-old bitches that were divided into three groups: two experimental ones and a control group. The experimental animals were orally administered zearalenon at 25 μg/ kg BW (body weight) (group DI; n=3) and 50 μg/kg BW (group DII; n=3) throughout 100 days while the control bitches (group K; n=3) were administered placebo. After the period of 100 days, ovariohysterectomy was performed, and the uterine samples were submitted to histopathological and immunohistochemical examinations in order to determine the structure of the wall and the presence of PCNA antigen. In the experimental animals, the histopathological examinations revealed regressive lesions, such as degeneration and atrophia within the endometrium and myometrium, and local circulatory disorders, i.e. edema and extravasation. These lesions were not reported in the controls. In the bitches administered zearalenon, the tissues did not express any proliferative activity as determined by the presence of PCNA. It is assumed that, following the administration of zearalenon for 100 days orally to bitches, disruption of the structures within the wall of the uterus (i.e. degeneration, atrophy, edema, and extravasation within the endometrium and myometrium) develops. This research proves that zearalenon ingested by bitches may lead to dysfunction of the uterus and cause disruption of its structures.

Słowa kluczowe

PL

uterus; veterinary protection; bitch; histopathology; zearalenone; proliferation activity; animal disease; mycotoxicosis

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2007
• Tom: 10
• Numer: 3
• Opis fizyczny: p.143-151,fig.,ref.

Twórcy

autor

Gajecka M.

• University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland

autor

Janowski T.

autor

Jakimiuk E.

autor

Polak M.

autor

Podhalicz-Dziegielewska M.

autor

Rotkiewicz T.

autor

Otrocka-Domagala I.

autor

Obremski K.

autor

Zielonka L.

autor

Gajecki M.

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