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2005 | 54 | 4 |

Tytuł artykułu

The susceptibility of anaerobic bacteria isolated from periodontal diseases to photodynamic inactivation with Fotolon [chlorin e6]

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Photodynamic inactivation (PDI) may be a very promising alternative method for the antimicrobial treatment of periodontitis. Several studies have demonstrated the sensitivity of subgingival flora to PDI using toluidine blue, methylene blue, and chlorin e6 derivatives. In the present study we report the activity of the Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against anaerobic bacteria isolated from periodontal diseases. Over 99.9% reduction in colony forming units in 20 Gram-positive and 30 Gram-negative clinical anaerobic strains was obtained.

Wydawca

-

Rocznik

Tom

54

Numer

4

Opis fizyczny

p.305-310,fig.,ref.

Twórcy

  • University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland
autor

Bibliografia

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  • Embleton M.L., P.N. Sean, B.D. Cooks on and M. Wilson. 2002. Selective lethal photosensitization of methicillin resistant Staphylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate. J. Antimicrob. Chemother. 50: 857-864
  • Hamblin M.R., D.A. O'Donnell, N. Murthy, K. Rajagopalan, N. Michaud, M.E. Sherwood and T. Hasan. 2002. Polycationic photosensitizers conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria. J. Antimicrob. Chemother. 49: 941-951.
  • Hamblin M.R., T. Zahra, C.H. Con tag, A.T. McManus and T. Hasan. 2003. Optical monitoring and treatment of potentially Lethal Wound Infections in vivo. J. Infect. Dis. 187: 1717-1725.
  • Jacob H.E. and M. Hamann. 1975. Photodynamic alterations of the cell envelope of Proteus mirabilis and their repair. Photochem. Photobiol. 22: 237-241.
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  • Kömerik N., H. Nakanishi, A.J. MacRobert, B. Henderson, P. Speight and M. Wilson. 2003. In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model. Antimicrob. Agents Chemother. 47: 932-940.
  • Menezes S., M.A.M. Capella and L.R. Caldas. 1990. Photodynamic action of methylene blue: repair and mutation in Escherichia coli. J. Photochem. Photobiol. B: Biol. 5: 505-517.
  • Merchat M., G. Bertoloni, P. Giacomoni, A. Villanueva and G. Jori. 1996. Meso-substituted cationic porphyrins as efficient photosensitizers of Gram-positive and Gram-negative bacteria. J. Photochem. Photobiol. 32: 153-157.
  • Parkhots M.V., V.N. Knyukshto, G.A. Isakov, P.T. Petrov, S.V. Lepeshkevich, A. Ya. Khairullina and B.A. Dzhagarov. 2003. Spectral-luminescent studies of th "Photolon" photosensitizer in model media and in blood of oncological patients. J. App. Spectr. 70: 921-926.
  • Pfitzner A., B.W. Sigusch, V. Albrecht and E. Glockmann. 2004. Killing of periodontopathogenic bacteria by photodynamic therapy. J. Periodontal. 10: 1343-1349.
  • Rovaldi C.R., A. Pievsky, N.A. Sole, P.M. Friden, D.M. Rothstein and P. Spacciapoli. 2000. Photoactive porphyrin derivative with broad-spectrum activity against oral pathogen in vitro. Antimicrob. Agents Chemother. 44: 3364-3367.
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  • Soukos N.S., L.A. Ximenez-Fyvie, M.R. Hamblin, S.S. Socransky and T. Hasan. 1998. Targeted antimicrobial photochemotherapy. Antimicrob. Agents Chemother. 42: 2595-2601.
  • Soukos N.S., M. Wilson, T. Burns and P.M. Speight. 1996. Photodynamic effects of toluidine blue on human oral keratinocytes and fibroblasts and Streptococcus sanguis evaluated in vitro. Lasers Surg. Med. 18: 253-259.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-d135e79a-d4b8-47f6-b42b-5f9e96e25307
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