Kaempferol, but not resveratrol inhibits angiotensin converting enzyme

• Autorzy: Olszanecki R. , Bujak-Gizycka B. , Madej J. , Suski M. , Wolkow P.P. , Jawien J. , Korbut R.
• Języki publikacji: EN

Abstrakty

EN

Inhibition of angiotensin converting enzyme (ACE) has proved to be beneficial in the treatment of various cardiovascular disorders. The aim of this study was to evaluate ACE inhibitory potential of two polyphenolic compounds with different structures: resveratrol (present in high quantities in French wine) and kaempferol (abundant in greens), using method of liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI-MS) for ex vivo measurement of angiotensin I to angiotensin II conversion by ACE in aortic tissue of Wistar-Kyoto rats. In this setting, kaempferol (10-30-100 µM), but not resveratrol (10-30-100 µM) appeared to inhibit dose-dependently conversion of Ang I to Ang II. Although the mechanism of ACE inhibition by kaempferol remains to be elucidated, this observation may help in search or designing of new classes of ACE inhibitors.

Słowa kluczowe

EN

hypertension; kaempferol; flavonoids; angiotensin I; cardiovascular disorder; resveratrol; angiotensin II; French wine; angiotensin converting enzyme

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2008
• Tom: 59
• Numer: 2
• Opis fizyczny: p.387-392,fig.,ref.

Twórcy

autor

Olszanecki R.

• Jagiellonian University School of Medicine, 16 Grzegorzecka str., 31-531 Krakow, Poland

autor

Bujak-Gizycka B.

autor

Madej J.

autor

Suski M.

autor

Wolkow P.P.

autor

Jawien J.

autor

Korbut R.