The morphological and histochemical neurosecretory magnocellular system in the rat after administration of chlorpromazine

• Autorzy: Arciszewska E , Borowska H. , Sawicki B.
• Języki publikacji: EN

Abstrakty

EN

The effect of chlorpromazine (CPZ) on the neurosecretory action of the hypothalamo-hypophyseal system was investigated in 72 male rats. The experimental animals received CPZ in a dose of 0.4 mg, 4.0 mg and 20.0 mg/kg b.w. for 30 days. The rats were sacrificed by decapitation at 24 h and 7 days after the last dose of the drug. The neurosecretory material was stained with paraldehyde fuchsin in the supraoptic nucleus, paraventricular nucleus, eminentia mediana and neurohypophysis, the tigroid was stained with toluidine blue and the acid phosphatase activity was evaluated histoenzymatically. It was found that CPZ reduced the content of the neurosecretory material after 24 h, while an increase was observed 7 days after the last drug administration.

Słowa kluczowe

EN

magnocellular neurosecretory system; hypothalamo-hypophyseal system; acid phosphatase; neurosecretory action; experimental animal; morphology; rat; chlorpromazine; histochemistry; drug administration

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2004
• Tom: 63
• Numer: 1
• Opis fizyczny: p.83-85,fig.,ref.

Twórcy

autor

Arciszewska E

• Medical University, Kilinskiego 1, 15-089 Bialystok, Poland

autor

Borowska H.

autor

Sawicki B.

Bibliografia

• 1. Bock R, Brinkman H, Marckwort W (1968) Farberische Beobachtungen zur Frage nach dem primären Bildunsort von Neurosekret in supraoptico-hypophysären. System. Z Zellforsch Mikrosk Anat, 87: 534–544.
• 2. Else PL, Mansfield K (1997) Activation of sodium transport and intracellular sodium lowering by the neuroleptic drug chlorpromazine. Biochem Pharmacol, 54: 275–281.
• 3. Eström H, Hausson HA, Noström A (1973) The effect of chlorpromazine and tetracaine on the rapid axonal transport of neurosecretory material in the hypothalmo neurohypophysial system of the rat. Z Zellforsch, 143: 71–91.
• 4. Galfi M, Janaky T, Toth R, Prohaszka G, Juhasz A, Varga C, Laszlo FA (2001) Effects of dopamine and dopamine — active compounds on oxytocin and vasopressin production in rat neurohypophyseal tissue cultures. Regul Pept, 98: 49–54.
• 5. Onaka T, Yamashita T, Liu X. Honda K, Saito T, Yagi K (2001) Medullary A1 noradrenergic neurones may mediate oxytocin release after noxious stimuli. Neuroreport 12: 2499–2502.