Dietary origin of mycotoxins with estrogenic potential and possible health implications to female dogs

• Autorzy: Golinski P.K. , Nowak T.
• Języki publikacji: EN

Abstrakty

EN

In Poland, occurrence of toxigenic fungi in cereals, foods, feeds and their components as well as mycotoxins accumulation in such material has been studied by numerous teams including our research group for over thirty years since 1969. Mostly cereal kernels and feeds have been examined for presence of toxigenic fungi, their toxigenic potential and natural contamination with mycotoxins. Ochratoxin A, deoxynivalenol, nivalenol and moniliformin were found to be significant contaminants of agricultural products in high percentage of cereal grain samples. The profile of toxic metabolites was similar but the concentration levels of the toxins were lower when compared to already published data of the same climate zone. Zearalenone (ZEA), a nonsteroidal mycotoxin with estrogen-like activity, is synthesized by molds (Fusarium) commonly contaminating poorly stored agricultural products and foodstuffs. Since in the course of examinations and during surgical procedures performed in dogs, ovarian cysts were detected and because frequently this is the first stage of the endometrica pyometra complex (EPC) found in approximately 30% of the females we assume that both factors, mycotoxins (ZEA) and pathological aberrations are possibly related in these animals. Similar activity of the toxin (possibly present in pelleted dog feed) and effects including infertility of female dogs is speculated with indication and suggestion on necessity of additional studies on the problem.

Słowa kluczowe

EN

mycotoxin; zearalenone; toxicity; dog; food; fungi; cereal; reproductive toxicity; female; estrogenic metabolite; feed

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2004
• Tom: 07
• Numer: 4
• Opis fizyczny: p.337-341,ref.

Twórcy

autor

Golinski P.K.

• August Cieszkowski Agricultural University, Wojska Polskiego 75, 60-025 Poznan, Poland

autor

Nowak T.

Bibliografia

• Bottalico A (1998) Fusarium diseases of cereals, species complex and related mycotoxins profiles in Europe. J Plant Pathol 80: 85-103.
• Chelkowski J, Golinski P (1982) Mycotoxins and toxigenic fungi in mixed feeds and their cereal components. Pro­ceedings of V Inter IUPAC Symposium on Mycotoxins and Phytotoxins, Technical University, September 1-3, Vienna, Austria, 68-71.
• Chelkowski J (1989) Formation of mycotoxins produced by Fusaria in heads of wheat, triticale and rye. In: Chel­kowski J (ed) Fusarium: Mycotoxins, Taxonomy and Pathogenicity. Elsevier, Amsterdam, pp 63-84.
• Chelkowski J (1991) Fungal pathogens influencing cereal seed quality at harvest. In: Cereal Grain - Mycotoxins, Fungi and Quality in Drying and Storage. Elsevier, Am­sterdam pp 53-66.
• Chelkowski J (1998) Distribution of Fusarium species and their mycotoxins in cereal grains. In: Mycotoxins in Ag­riculture and Food Safety (KK Sinha and D Bathnagar eds), Marcel Dekker Inc New York pp 45-64.
• Chelkowski J, Perkowski J, Grabarkiewicz-Szczesna J, Ko­stecki M, Golinski P (2001) Toxigenic fungi and my­cotoxins in cereal grains and feeds in Poland. In: Log- rieco A (ed) Occurrence of toxigenic fungi and my­cotoxins in plants, food and feed in Europe. COST Ac­tion 835, European Commission, pp 111-130.
• EC (2000) Opinion of the scientific Committee of Euro­pean Commission on Food on Fusarium toxins. Part 2: Zearalenone (ZEA).
• Frithsche S, Steinhart H (1999) Occurrence of hormonally active compounds in food: a review. Eur Food Technol 209: 153-179.
• Gareis M, Bauer J, Enders C and Gedek B (1989) Con­tamination of cereals and feed with Fusarium my­cotoxins in European countries. In: Chelkowski J (ed) Fusarium - Mycotoxins, Taxonomy and Pathogenicity. Elsevier, Amsterdam, pp 441-467.
• Golinski PK, Hult K, Grabarkiewicz-Szczesna J, Chel­kowski J, Kneblewski P, Szebiotko K (1984) Mycotoxic porcine nepropathy and spontaneous occurrence of och- ratoxin A residues in kidneys and blood of Polish swine. Apple Envir Microb 47: 1210-1212.
• Golinski PK, Hult K, Grabarkiewicz-Szczesna J, Chel­kowski J, Kneblewski P, Szebiotko K (1985) Sponta­neous occurrence of ochratoxin A residues in porcine kidney and serum samples in Poland. Appl Envir Microb 49: 1014-1015.
• Golinski PK (1987) Ochratoxin A in human being organ­ism as a result of food and animal feed contamination with the mycotoxins. Ann Agric Univ of Poznań 168: 1-64.
• Golinski PK , Vesonder RF, Latus-Zietkiewicz D, and Per­kowski J (1988) Formation of fusarenone X, nivalenol, zearalenone, a-trans-zearalenol, (3-trans-zearalenol, and fusarin C by Fusarium crookwellense. Appl Environ Microbiol 54: 8, 2147-2148.
• Golinski PK, Perkowski J, Kostecki M, Grabarkiewicz- -Szczesna J, Chelkowski J (1996a) Fusarium species and Fusarium toxins in wheat in Poland. Sydowia 48: 12-22.
• Golinski PK, Kostecki M, Lasocka I, Wiśniewska H, Chel­kowski J, Kaczmarek A (1996b) Moniliformin accumu­lation and other effects of Fusarium avenaceum (FR.) Sacc. On kernels of winter wheat cultivars. J Phytop 144: 495-499.
• Golinski PK, Kaczmarek A, Kiecana I, Wiśniewska H, Ka­ptur P, Kostecki M, Chelkowski J (2002) Fusarium headblight of common Polish winter wheat cultivars - com­parison of effects Fusarium avenaceum and F. colmorum on yield components. J Phytop 150: 135-141.
• Golinski P, Kostecki M, Golinska B, Golinska BT, Golinski PK (2003) Accumulation of mycotoxins in forage of winter pasture during prolongated utilisation of sward. Pol J Vet Sci 6: 81-86.
• Golinski P, Kostecki M, Golinska B, Golinska BT, Golinski PK (2004) Accumulation of mycotoxins in forage of winter pasture during prolongated utilisation of sward (under preparation).
• Hult K (1991) Occurrence of ochratoxin A in swine blood as an indicator of mould activity in cereal grain. In: Chelkowski J (ed) Cereal Grain - Mycotoxins, Fungi and Quality in Drying and Storage, Elsevier, Amster­dam, pp 297-309.
• JECFA (2000) Joint FAO/WHO Expert Committee on Food Additivies, 53rd Report. Safety evaluation of cer­tain food additivies. WHO Food Additivies Series 44 (in print).
• Kuiper GG, Lemmen JG, Carlsson BM, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA (1998) Interac­tion of estrogenic chemicals and phytoestrogens with es­trogen receptor beta. Endocrinol 139: 4252-4263.
• Latus-Zietkiewicz D, Perkowski J, Chelkowski J (1995) Mycotoxins productions, pathogenicity and toxicity of Fusarium species isolated from potato tubers with dry rot injuries. Microbiol Alim Nutr 13: 87-100.
• Perkowski J, Plattner RK, Golinski P, Vesonder RF (1990) Natural occurrence of deoxynivalenol, 3-acetyl- -deoxynivalenol, 15-acetyl-deoxynivalenol, nivalenol, 4,7-dideoxynivalenol, and zearalenone in Polish wheat. Mycotoxin Research 6: 7-12.
• Perkowsi J (1993) Production of mycotoxins in cereals by fungi of the genus Fusarium. Postępy Nauk Rolniczych 242: 67-82.
• Perkowski J (1999) Badania zawartości toksyn fuzaryjnych w ziarnie zboz. Rocz AR Poznan Rozprawy Naukowe 295: 1-136.
• Tomaszewski J, Miturski R, Semczuk A, Kotarski J Jakowicki J (1998) Tissue zearalenone concentration in normal, hyperplastic human endometrium. Ginekol Pol 69: 363-366.
• Tomczak M, Wiśniewska H, Stepien L, Kostecki M, Chel- kowski J, Golinski P (2002) Deoxynivalenol, nivalenol and moniliformin in wheat samples with head blight (scab) symtoms in Poland (1998-2000). Europ J Plant Path 108: 625-630.
• Vesonder RF, Golinski PK (1989) Metabolites of Fusar­ium. In\ Chelkowski J (ed) Fusarium: Mycotoxins, Tax­onomy and Pathogenicity. Elsevier, Amsterdam, Oxford, NY, Tokyo, pp 1-39.
• Visconti A, Mirocha CJ, Bottalico A, Chelkowski J (1985) Trichothecene mycotoxins produced by Fusarium sporotrichioid.es strain P-11. Mycotoxin Res 1: 3-10.