Serum vitamin E and malondialdehyde concentrations in experimentally induced Mannheimia [Pasteurella] haemolytica infection in ewes fed dam milk or cow milk after birth

• Autorzy: Orbay A E , Altiner A.
• Języki publikacji: EN

Abstrakty

EN

Twenty Chios newborn ewe lambs were used. Ten lambs were fed ad libitum colostrum and dam milk (group 1). The other ten lambs were separated from their dams immediately after birth and were not allowed to suckle normally, but were fed commercial cow's milk with a feeding bottle (group 2). When they were one year old, M. haemolytica serotype Al (10⁹ germs) was inoculated intratracheally to each ewe. Serum vitamin E and malondialdehyde (MDA) concentrations were determined in all the sheep before inoculation, and on days 1, 10, and 22 after inoculation, in addition to day 7 after antibiotic treatment. Serum vitamin E concentrations significantly decreased on day 1 after bacterial inoculation in group 1, rose on day 10 and continued to rise on day 22 after inoculation. The concentrations of the compounds did not significantly differ from the values observed on day 22 after antibiotic administration (on day 7 after treatment). Vitamin E concentration significantly decreased on day 1 after inoculation in group 2, and significantly rose on day 10 and then remained constant. Significant differences were observed between groups 1 and 2 before inoculation (P≤0.05). While serum vitamin E concentration of group 1 was higher than group 2 before inoculation, the concentrations in group 2 were significantly higher than in group 1 on days 10 and 22 after inoculation. Serum MDA concentrations gradually significantly increased in groups 1 and 2 after bacterial inoculation (P≤0.05), and then decreased to the pre-inoculation values after antibiotic treatment. No significant difference was observed between group 1 and group 2 on any sampling day. In conclusion, M. haemolytica infection induced lipid peroxidation associated with a rapid consumption of the antioxidant vitamin E (day 1), following by mobilisation of liver vitamin stores, probably more intense in ewes fed artificially after birth. The similar serum MDA concentrations in the two groups suggests that, a resistance against an infection can develop in sheep fed with artificially cow's milk within one year, but the effects of repeated infections on such animals still remains to be explored.

Słowa kluczowe

EN

vitamin E; infection; newborn ewe; colostrum; mammal; Mannheimia haemolytica; malondialdehyde; ewe; infectious disease; lamb

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2007
• Tom: 51
• Numer: 2
• Opis fizyczny: p.207-211,ref.

Twórcy

autor

Orbay A E

• Pharma Vision Pharmaceutical Company, 34010 Zeytinburnu, Instanbul, Turkey

autor

Altiner A.

Bibliografia

• 1. Altıner A., Oztabak K., Ulutas P.A., Ozpinar A.: Relationship of inflammatory cytokines with experimental Mannheimia haemolytica infection in ewes fed dam milk or cow milk after birth. Medycyna Wet 2005, 61, 1355-1358.
• 2. Bains B.S.: Vitamin E and immunity in poultry. World Poult 1994, 10, 51.
• 3. Bieri J.G., Tolliver T.J., Catignani G.L.: Simultaneous determination of α-tocopherol and retinol in plasma or red cells by high-pressure liquid chromatography. Am J Clin Nutr 1979, 32, 2143-2149.
• 4. Chawla R., Kaur H.: Plasma antioxidant vitamin status of periparturient cows supplemented with α-tocopherol and ß-carotene. Anim Feed Sci Technol 2004, 114, 279-285.
• 5. Confer A.W., Panciera R.J., Mosier D.A.: Bovine pneumonic pasteurellosis: Immunity to Pasteurella haemolytica. J Am Vet Med Assoc 1988, 193, 1308- 1316.
• 6. Daniels J.T., Hatfield P.G., Burgess D.E., Kott R.W., Bowman J.G.P.: Evaluation of ewe and lamb immune response when ewes were supplemented with vitamin E. J Anim Sci 2000, 78, 2731-2736.
• 7. Daryani R., Lalonde C., Zhu D., Demling R.H.: Changes in catalase activity in lung and liver after endotoxemia in sheep. Circ Shock 1990, 32, 273-280.
• 8. Demling R., Lalonde C., Seekamp A., Fiore N.: Endotoxin causes hydrogen peroxide-induced lung lipid peroxidation and prostanoid production. Arch Surg 1988, 123, 1337-1341.
• 9. Dominguez E., Perez M.D., Puyol P., Sanchez L., Calvo M.: Specific immunoglobulins in serum of newborn lambs fed with a single dose of colostrum containing anti-peroxidase IgG. Res Vet Sci 2001, 70, 275-279.
• 10. Erkurt A.: Blood lipid peroxidation and enzymatical antioxidant systems (malondialdehyde, catalase, superoxide dismutase, glutathion peroxidase) in the cows with ketosis and in the experimental ketosis cases in rabbits. 95 pages, PhD Thesis, Univ Ankara, Ankara, 1999.
• 11. Fry J.M., Smith G.M., McGrath M.C., Speıjers E.J., Allen J.G.: Plasma and tissue concentrations of α- tocopherol during vitamin E depletion in sheep. British J Nutr 1993, 69, 225-232.
• 12. Gaal T., Mezes M., Miskucza O., Ribiczey-Szabo P.: Effect of fasting on blood lipid peroxidation parameters of sheep. Res Vet Sci 1993, 55, 104-107.
• 13. Hodgins D.C., Shewen P.E.: Vaccination of neonatal colostrum-deprived calves against Pasteurella haemolytica A1. Can J Vet Res 2000, 64, 3-8.
• 14. Inanami O., Shiga A., Okada K., Sato R., Miyake Y., Kuwabara M.: Lipid peroxides and antioxidants in serum of neonatal calves. Am J Vet Res 1999, 60, 452-457.
• 15. Pehrson B., Hakkaraninen J., Blomgren L.: Vitamin E status in newborn lambs with special reference to the effect of dl-α-tocopherol acetate supplementation in late gestation. Acta Vet Scand 1990, 31, 359-367.
• 16. Seekamp A., Lalonde C., Zhu D.G., Demling R.: Catalase prevents prostanoid release and lung lipid peroxidation after endotoxemia in sheep. J Appl Physiol 1988, 65, 1210-1216.
• 17. Snedecor G.W., Cochran W.G.: Statistical Methods. 7th ed., Iowa State University Press, Ames, USA, 1980.
• 18. Tanaka J., Fujiwara H., Torisu M.: Vitamin E and immune response, enhancement of helper T-cell activity by dietary supplementation of vitamin E in mice. Immunology 1979, 38, 727-734.
• 19. Tengerdy R.P.: Immunity and disease resistance in farm animals fed with vitamin E supplement. Adv Exp Med Biol 1990, 262, 103-110.
• 20. Turan N.: Investigation with serological tests of Salmonella enteritidis and Salmonella typhimurium antibodies in broiler's and laying hen's sera and experimental infection studies. PhD Thesis, University of Istanbul, Istanbul, 1995.
• 21. Ulutas P.A., Ozpinar A.: Effect of Mannheimia (Pasteurella) haemolytica infection on acute-phase proteins and some mineral levels in colostrum-breast milk-fed or colostrum-breast milk-deprived sheep. Vet Res Com 2006, 30, 485-495.
• 22. Wong C., Flynn J., Demling R.H.: Role of oxygen radicals in endotoxin-induced lung injury. Arch Surg 1984, 119, 77-82.
• 23. Youn Y.K., Knox J., Lalonde C., Demling R.: Pentoxifylline does not prevent endotoxin induced lung and liver lipid peroxidation in the adult sheep. Circ Shock 1993, 39, 39-43.