Atopic eczema: genetics or environment?

• Autorzy: Wuthrich B , Cozzio A. , Roll A. , Senti G. , Kundig T. , Schmid-Grendelmeier P.
• Języki publikacji: EN

Abstrakty

EN

Atopic eczema (AE) is a multifactorial skin disease caused by a variety of factors such as genetic conditions, alterated skin structure, immunologic deviations and environmental factors, among others. There are two main subtypes of AE, i.e. the IgE-associated (“atopic eczema”) and the non-IgE-associated type (“nonatopic eczema”) with different prognosis concerning the development of respiratory diseases (“atopy march”). Recently, it was demonstrated that Filaggrin (= fi lament-aggregating protein, FL) is a major gene for atopic eczema. Filaggrin binds to and aggregates the keratin cytoskeleton in the epidermis. Homozygous FLG mutation leads to complete loss of fi laggrin expression in skin. Half or more of children with moderate to severe AE carry FLG mutations. Moreover, fi laggrin loss-of-function mutations predispose to phenotypes involved in the atopy march. The altered skin structure and a defi ciency in antimicrobial peptides favour colonization with Staphylococcus aureus and yeasts (Malassezia sp.). Sensitization to the yeast occurs almost exclusively in AE patients. S. aureus enterotoxins with superantigenic activity stimulate activation of T cells and macrophages. So far, AE skin lesions are orchestrated by the local tissue expression of proinfl ammatory cytokines and chemokines with activation of T lymphocytes, dendritic cells, macrophages, keratinocytes, mast cells, and eosinophils which lead to the skin infl ammatory responses. From the therapeutic point of view, besides emollients and local corticosteroids, topic immunomodulatory drugs (tacrolimus and pimecrolimus) have substantially improved the treatment of AE.

Słowa kluczowe

EN

inflammatory skin disease; environmental factor; food; atopy patch test; non-atopic eczema; Staphylococcus aureus; contact allergen; chronic disease; human disease; genetic condition; therapy; Malassezia sympodialis; skin disease; immunological deviation; atopic eczema; skin structure; skin infection; skin barrier

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2007
• Tom: 14
• Numer: 2
• Opis fizyczny: p.195-201,ref.

Twórcy

autor

Wuthrich B

• Spital Zollikerberg, Trichtenhausrstasse 20, 8125 Zollikeberg, Switzerland

autor

Cozzio A.

autor

Roll A.

autor

Senti G.

autor

Kundig T.

autor

Schmid-Grendelmeier P.

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