The study of cell and tissue mechanisms of the homeostasis of helminth-host system at muscle trichinellosis before and after the administration of a herb biostimulator and anthelminthic

• Autorzy: Movsessian S , Goncharova G. , Asatrian A. , Nikoghossian M. , Malczewski A.
• Języki publikacji: EN

Abstrakty

EN

Results of micromorphological and histological studies of larvae of Trichinella Spiralis and T. pseudospiralis, as weil as, muscles, liver and small intestine of the rat-host before and after biostimulator administration of phytohemagglutinin and phytoanthelminthic were presented. It has been established that rats with Trichinella larvae of both species developed unspecific allergic angiomyositis, hepatitis, cholangitis, and erosio-haemorrhagic enterocolitis in the host's organism on the 35th day after infection. Furthermore, processes of compensatory hypertrophy, that support the host's (rats) homeostasis, on cell and tissue levels, were observed at histodestructional and morphofunctional deficiency. lt has been revealed that phytohemagglutinin, biostimulator injected into the host's organism before infection, is of immunostimulating nature and partially destroys the larvae of Trichinella. The phytoanthelminthic produces a significant trichinellocide effect: RNA synthesis and glycogen is intensified in the organs of the treated animals, their pathomicromorphogenesis weakened, and their compensatory and regenerative processes were observed. The combined use of the phytohemagglutinin and phytoanthelminthic fails to intensify the mentioned effect.

Słowa kluczowe

EN

herb; host-parasite system; anthelminthic treatment; muscle; homeostasis; trichinellosis; phytotherapy; tissue mechanism; helminth parasite; cellular mechanism; Trichinella spiralis; host

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2003
• Tom: 49
• Numer: 2
• Opis fizyczny: p.195-217,fig.,ref.

Twórcy

autor

Movsessian S

• Russian Academy of Sciences, Lenin'av.33, 119071 Moscow, Russia

autor

Goncharova G.

autor

Asatrian A.

autor

Nikoghossian M.

autor

Malczewski A.

Bibliografia

• Bekish O. Ya., Nikulin Yu.T. 1996. [Histological and histochemical characteristics of adrenal glands at experimental trichinellosis]. XII Scientific Conference on Trichinellosis of Man and Animals. Proceedings, Moscow, 5-7 (in Russian).
• Błotna M. 1967. Ultrastructural change in muscle fibers in trichinellosis. Acta Medica Polonica 8: 403-405.
• Bogoyavlensky Yu.K., Grishina E.A., Mushkambarova M.G. 1992. [The pathomorphology of host's tissues and organs after using anthelminthics]. ,,llish '' Ashkhabad (in Russian).
• Borzuchowska A., Kuroczycka-Seniutycz I. 1988. Efekty immunologiczne stosowanego leczniczo levamisolu u chorych z chorobą włośnicową. Materiały Naukowe XI Zjazdu Polskiego Towarzystwa Epidemiologów i Lekarzy Chorób Zakaźnych, Puławy 16-18 września 1988, 246-249.
• Cocker C. 1956. Effects of cortisone on cellular inflammation in the musculature of mice given one infection with Trichinella spiralis. Journal of Parasitology 42: 479-484.
• De Nollin S., Borgers M., Van Parijs O., Van Den Bossche H. 1974. Effect of mebendazole on the encysted phase of Trichinella spiralis in the rats: an electron-microscope study. Parasitology 69: 55-62.
• Froltsova A.E., Astafev B.A., Konovalova L.M. 1965. [Searches for a specific therapy of the trichinellosis. I. Akrichin, chlorophos, monomicin, and NRV at experimental trichinellosis of rats]. Medical Parasitology and Parasitic Diseases 34: 387-390 (in Russian).
• Froltsova A.E., Ozeretskovskaya N.N., Kolosova M.O., Konovalova L.M. 1966. [Searches for a specific therapy of trichinellosis. II. Thiabendazolum at experimental trichinellosis of rats]. Medical Parasitology and Parasitic Diseases 35: 102-106 (in Russian).
• Gabryel P., Gustawska L., Błotna M., Kasprzak K., Rodola P. 1969. Pathomorphology of muscular trichinelliosis in comparative histological, histochemical, ultrastructural, autoradiographic and immunofluorescent investigation. Wiadomości Parazytologiczne 15: 655-657.
• Gerwel Cz., Pawłowski Z., Kocięcka W., Chodera L. 1974. Probable sterilization of Trichinella Spiralis by thiabendazole: further clinical observation of human infections. In: Trichinellosis. Proceedings of the Third International Conference on Trichinellosis (Ed. Ch.W. Kim), 471-475 .
• Giełdanowski J., Ślopek S., Kowalczyk-Bronisz S. 1980 Immunobiological and pharmacological properties of Thymus Factor X (TFX). II. Immunotropic activity. Archivum Immunologiae et Therapiae Expermentalis 28: 853-857.
• Goncharova G.V., Lukshina L.M., Movsessian S.O., Asatrian A.M., Nikoghossian M.A., Valova T. I. 1997a. [The effect of phytohemagglutinin and phytoanthelminthic on muscle trichinellosis]. Manuscript deposit in VINITI 29.10.97, 3175-B-97, Moscow (in Russian).
• Goncharova G. V., Lukshina L.M., Movsessian S.O., Asatrian A.M., Nikoghossian M.A., Valova T.I. 1997b. [Micromorphological study of host's liver and intestine at muscle trichinellosis after phytoanthelminthic and phytohemagglutinin]. Manuscript deposit in VI NITI 29.10. 97, 3176-B-97, Moscow (in Russian).
• Januszkiewicz J., Kowalczyk M., Poznańska H., Wehr H. 1969. Liver involvement in trichinellosis. Wiadomości Parazytologiczne 15: 724-725.
• Jaszcz W., Rzepeski W., Wojciechowski Z., Piotrowska K. 1980. Studies on the biological activity of Thymus Factor X (TFX). II. The Effect of TFX on the pictures of the blood and lymphatic organs of thymectomized mice in the post-neonatal period. Patologia Polska 31: 273-285.
• Kocięcka W., Budzyńska L. 1985. Eosinophilia in patients with trichinellosis treated with corticosteroids and various anthelmintics. In: Trichinellosis. Proceedings of the Sixth International Conference on Trichinellosis (Ed. Ch.W. Kim), 321-327.
• Kocięcka W., Gerwel Cz., Pawłowski Z., Kaczmarek J., Stachowski B., Gabryel P., Gustowska L. 1974. Experimental trichinellosis and thiabendazole treatment in Macaca mulatta: clinical and electromyographic observation. In: Trihinellosis Proceedings of the Third International Conference on Trichinellosis (Ed. Ch.W. Kim), 123-133.
• Kocięcka W., Rauhut W., Gustowska L. 1989. The effect of Thymus Factor X (TFX Polfa) on Trichinella Spiralis muscle invasion in mice. Parasitological and histological study. Wiadomości Parazytologiczne 35: 413-421.
• Kocięcka W., Gustowska L., Iwanow M., Rauhut W. 1992. Parasitological and histological study in experimental trichinellosis of mice freated with TFX-thymomodulin. Mitteilungel Österreichischen Gesellschaft Tropenmedizin und Parasitologie 14: 13-20.
• Łapszewicz A., Pawłowski Z., Gabryel P. 1969. Thiabendazole in human trichinellosis. Wiadomości Parazytologiczne 15: 759-760.
• Mittermayer T., Spaldonova R. 1981. The use of mebendazole in the treatment of trichinellosis in man. Folia parasitologica, Praha 28: 235-245.
• Novik T.S., Veretennikova N.L., Bessonov A.S., Skvortsova F.K., Astafev B.A., Ryabova V.A., Kovalenko F.P. 1997. [The effectiveness of the lyposomal forms of albendazolum at experimental trichinellosis of white rats]. All-Russian Symposium ,,The Role of Russian Helminthological Schools in the Development of Parasitology '' Proceedings, Moscow, 36 (in Russian).
• Ozeretskovskaya N .N. 1965. [The effect of the steroide therapy on acute period of trichinellosis and during the period of reconvalescence. I. Effect of steroide therapy on on-end period of swellings, fever, mialgia and total duration of the disease]. Medical Parasitology and Parasitil Diseases 34: 379-387 (in Russian).
• Ozeretskovskaya N.N. 1970. [Formation of the pathological process in acute and chronic phases of helminthosis]. Medical Parasitology and Parasitic Diseases 39: 515-521 (in Russian).
• Ozeretskovskaya N.N., lvanova M.G., Michailova O.D. 1958. [Experiment of treatment of trichinellosis with AKTH and cortizonum]. Soviet Medicine 9: 111-119 (in Russian).
• Ozeretskovskaya N.N., Potekaeva M.A., Tumolskaya N.I., Margulis T.D., Vishnevsky B.A. 1966a. [The influence of steroid therapy on acute and convalescent periods of trichinellosis. II. The influence of steroid upon the clinical conditions and morphology of the muscle damages in trichinellosis]. Medical Parasitology and Parasitic Diseases 35: 164-171 (in Russian).
• Ozeretskovskaya N.N., Vichert A.M., Froltsova A.E., Konovalova L.M. 1966b. [On the pathogenesis of organic and systemic affection at trichinellosis]. II. Experimental trichinellose allergic encephalomielitis]. Medical Parasitology and Parasitic Diseases 35: 395-401 (in Russian).
• Ozeretskovskaya N.N., Pereverzeva E.V., Kolosova M.O., Chemijaeva A.I., Rimalis B. 1969a. On the mechanism of chemotherapeutic activity and similar effect of benzimidazolum at trichinellosis. Wiadomości Parazytologiczne 15: 682-684.
• Ozeretskovskaya N.N., Tumolskaya N.I., Vichert A.M., Zalnova N.S., Yermolin G.A., Bronshtein A.M. 1969b. [On the pathogenecity of organ and systemic lesions in trichinellosis. IV. On the pathogenesis of trichinellosis miocarditis]. Medical Parasitology and Parasitic Diseases 38: 521-528 (in Russian).
• Ozeretskovskaya N.N., Tumolskaya N.I., Pereverzeva E.V., Bronshtein A.M. 1976. [Thiabendazolum, chlophasol, and mebendazole in the treatment of synanthropic and sylvatic Trichinella Spiralis strains]. Proceedings of the II All-Union Confrence on the Problem of Trichinellosis of Man and Animals, June 3-4, 1976, Vilnius, 198-203 (in Russian).
• Ozeretskovskaya N.N., Pereverzeva E.Y., Tumolskaya N.I., Bronshtein A.M., Morenez T.M., lmamkuliev K.D. 1978a. Benzimidazoles in the treatment and prophylaxis of synanthropic and sylvatic trichinelosis. In: Trichinellosis. Proceedings of the Fourth International Conference on Trichinellosis (Eds. CH.W. Kim, Z.S. Pawłowski), 381-393.
• Ozeretskovskaya N.N., Tumolskaya N.I., Poverenny N.I., Pogorodnichenko Y.K. 1978b. [Nonspecific (immunomodelling) effect of new anthelminthics – natural imidazolum and benzidimidazolum]. In: Sci. and Appl. Probl. of Helminthol. ,,Nauka''. Moscow, 128-134 (in Russian).
• Pereverzeva E. V. 1967. [Histostructural and histochemical studies of muscle trichinellosis]. Abstract of Kand. Thes. VIGIS. Moscow, (in Russian).
• Pereverzeva E. V. 1975. [To the study of experimental trichinellosis in rats at the background of hydrocortizone and thiabendazolum]. Problemy Parazitologii. Materialy VIII Nauchnoj Konferencii Parazitologov USSR, Kiev, 2: 104-106 (in Russian).
• Pereverzeva E. V. 1976. Dynamics of morphological and histochemical changes at trichinellosis caused by various stamms. Proceedings of the II All-Union Conference on the Problem of Trichinellosis of Men and Animals, June 3-4, 1976, Vilnius, 58-62 (in Russian).
• Pereverzeva E.V., Ozeretskovskaya N.N. 1979. The influence of bezimidazoles on host cellular inflammatory infiltrations in the course of experimental trichinellosis. Wiadomości Parazytologiczne 29: 559-564.
• Pereverzeva E.Y., Ozeretskovskaya N.N., Veretennikova N.L., Kolosova M.O. 1976. Trichinellocyte activity of karbamatbenzimidazole and morphological changes in larvae and muscle tissue of the host at experimental trichinellosis. Proceedings of the II All-Union Conference on the Problems of Trichinellosis of Man and Animals, June 3-4, 1976, Vilnius, 154-159 (in Russian).
• Pereverzeva E.V., Veretennikova N.A., Ozeretskovskaya N.N. 1981. Effect of fenbendazol and karbendazol on experimental trichinellosis process in white rats. Journal of Medical Parasitology and Tropical Medicine 2: 46-50.
• Skvortsova F.K., Veretennikova N.L., Novik T.S., Likova N.I. 1996a. [The study of lyposomalum albendazolum and medaminume effect on the morphology of muscle Trichinella by the method of luminescent microscopy]. VII Scientific Conference on Trichinellosis of Man and Animals Proceedings, Moscow, 86-88 (in Russian).
• Skvortsova F.K., Veretennikova N.L., Novik T.S., Ryabova V.A. 1996b. [The pathomorphological changes at experimental trichinellosis of mice after the lyposome therapy]. VII Science Conference on Trichinellosis of Man and Animals. Proceedings, Moscow, 89-91 (in Russian).
• Stoyanov D.P., Nenov S.D. 1965. [Some histochemical changes in cell of guinea pigs infected with Trichinella Spiralis]. Medical Parasitology and Parasitic Diseases 34: 392-396 (in Russian).
• Ślopek S., Giełdanowski J., Kowalczyk-Bronicz S. 1980. Immunobiological and pharmacological properties of Thymus Factor X (TFX). I. Biological and pharmacological activity. Archivum Immunologiae et Therapiae Experimentalis 28: 827-851.
• Thienpont D., Vanparijs of., Vandesteen R. 1974. Anthelmintic and histopathological effects of mebendazole on Trichinella Spiralis in the rat. In: Trichinellosis. Proceedings of the Third International Conference on Trichinellosis (Ed. Ch. W. Kim), 515-527.
• Tsvetaeva N.P. 1970. Study of pathomorphism of helminthoses. Veterinariya 47 (11): 25-28. (in Russian).