A low dose of chlorfenvinphos affects hepatic enzymes in serum and antioxidant enzymes in erythrocytes and liver of rats

• Autorzy: Lukaszewicz-Hussain A , Moniuszko-Jakoniuk J.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to investigate the effect of chlorfenvinphos administered at a single dose of 0.02 LD50 on the activity of serum of liver damage indicatory enzymes, such as β-glucoronidase (BGR), acid phosphatase (AcP) and alanine and aspartate aminotransferases (ALT and AST), as well as on the activities of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and liver. The animals were divided into two groups: the control group, which received oil, and the experimental groups, which received oil solution of chlorfenvinphos at a dose of 0.02 LD50. After 1, 24 and 48 hours of intoxication with chlorfenvinphos the blood samples were collected and livers were quickly removed. This study indicates that acute intoxication with chlorfenvinphos administered at a dose of 0.02 LD50 leads to liver function disturbances, which is a likely result of increased generation of reactive oxygen species.

Słowa kluczowe

EN

chlorfenvinphos; superoxide dismutase; low dose; enzyme; erythrocyte; catalase; liver; rat

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2005
• Tom: 14
• Numer: 2
• Opis fizyczny: p.199-202,ref.

Twórcy

autor

Lukaszewicz-Hussain A

• Medical Academy, Mickiewicza 2c, 15-222 Bialystok, Poland

autor

Moniuszko-Jakoniuk J.

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