Wplyw benzo[ghi]perylenu na toksykokinetyke pirenu i aktywnosc deetylazy 7-etoksykumaryny u szczurow

• Autorzy: Gawlik M
• Języki publikacji: PL

Abstrakty

PL

Oceniono wpływ benzo(ghi)perylenu na toksykinetykę pirenu oraz aktywność enzymów mikrosomalnych szczura. Stwierdzono, że benzo(ghi)perylen podany trzykrotnie p.o. nie wpłynął znacząco na zmiany parametrów toksykokinetycznych pirenu podanego dożylnie i dożołądkowo. Natomiast w sposób istotny zwiększył aktywność enzymów mikrosomalnych wątroby szczura ocenioną na podstawie zmian aktywności deetylazy-7-etoksykuma- ryny.

EN

The toxicokinetics of pyrene and the ability to induce hepatic 7-ethoxycoumarin O-deethylase activity were studied in rats pretreated with benzo(ghi)perylene (BghiP). Blood pyrene concentration variations in i.v. and p.o. treated, control, and BghiP pretreated rats were similar. The values of the toxicokinetic parameters for pyrene in the control and BghiP pretreated rats were also comparable. On the other hand, the oxidation of 7-ethoxycoumarin by the microsomal enzymes was considerably enhanced by BghiP pretreatment. No correlation was observed between the effect of benzo(ghi)perylene on blood pyrene level and the enzymatic induction.

Słowa kluczowe

PL

szczury; weglowodory aromatyczne wielopierscieniowe; benzo[ghi]perylen; zwierzeta laboratoryjne; aktywnosc enzymatyczna; deetylaza 7-etoksykumaryna; toksykokinetyka; piren

EN

rat; polycyclic aromatic hydrocarbon; laboratory animal; enzyme activity; toxicokinetics; pyrene

• Wydawca: -
• Czasopismo: Bromatologia i Chemia Toksykologiczna
• Rocznik: 1999
• Tom: 32
• Numer: 3
• Opis fizyczny: s.271-278,rys.,tab.,bibliogr.

Twórcy

autor

Gawlik M

• Uniwersytet Jagiellonski, 30-688 Krakow, ul.Medyczna 9

Bibliografia

• 1. Ando M., Tamura K., Katagiri K.: Study on suspended particulate matter and polycyclic aromatic hydrocarbon in indoor and outdoor air. Arch. Occup. Environ. Healt. 1991; 63: 297-301
• 2. Brzeźnicki S., Przybylski H.: Oznaczanie wielopierścieniowych węglowodorów aromatycznych w środowisku pracy podczas produkcji aluminium. Med. Pr. 1996; 1: 1-8
• 3. Hani H.: Soil pollution Encyclopedia Agric. Sci; 1994; 4: 133-140
• 4. Angerer J., Mannschreck C., Gtindel J.: Biological monitoring and biolochemical effect monitoring of exposure to polycyclic aromatic hydrocarbons. Int. Arch. Occup. Environ. Health. 1997; 70: 365-377
• 5. IARC. Monographs on the evaluation on the carcinogenic risk of chemicals to humans. 1983; vol. 32. IARC, Lyon
• 6. Environmental carcinogens selected methods of analysis. Distribution of polycyclic aromatic hydrocarbons in environmental samples. International Agency For Research on Cancer. Lyon. 1979
• 7. Jongeneelen F.J.: Biological monitoring of environmental exposure to polycyclic aromatic hydrocarbons, 1-hydroxypyrene in urine of people. Toxicol. Lett. 1994; 72: 205-211
• 8. Boos K.S., Lintelmann J., Ketlrup A.: Coupled-column high-performance liquid chromatographic method for the determination of 1-hydroxypyrene in urine of subjects exposed to polycyclic aromatic hydrocarbons. J. Chromatogr. 1992; 600: 189-194
• 9. Reddy M.V., Hemminki K., Randerath K.: Postlabeling analysis of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. J. Toxicol. Environ. Health. 1991; 34: 177-185
• 10. Ou X., Ramos K.S.: Modulation of aortic protein phosphorylation by benzo(a)pyrene: Implication in PAH-induced atherogenesis. J. Biochem. Toxicology. 1992; 7: 147-154
• 11. Joanides C., Lum P.K., Parke D.V.: Cytochrome P-448 and the activation of toxic chemicales and carcinogenesis. Xenobiotica. 1984; 14: 119-138
• 12. Hughes N.C., Phillips D.H.: 32P - postlabelling analysis of the covalent binding of benzo(ghi)perylene to DNA in vivo and in vitro. Carcinogenesis. 1993; 14: 127-133
• 13. Hansen A.M., OmlandO., Poulsen O.M., Sherson D., SigsgaardT., Christensen I.M., Overgaard E.: Correlation between work process-related exposure to polycyclic aromatic hydrocarbons and urinary levels of a-naftol, /J-naphthylamine and 1-hydroxypyrene in iron foundry workers. Arch. Occup. Environ. Health. 1994; 65: 385-394
• 14. Moulin J., Wild P., Mantour B., Fournier-Betz M., Mur J.M., Smagghe G.: Mortality from lung cancer and cardiovascular diseases among stainles-steel producing workers. Cancer Causes Control. 1993; 4: 75-81
• 15. Karlehagen S., Andersen A., Ohlson C-G.: Cancer incidence among creosote-exposed workers. Scand. J. Work Environ. Health. 1992; 18: 26-29
• 16. Lipniak M., Brandys J.: Bestimmung von Pyrene in Rattengewebe. Fresenius Z. Anal. Chem. 1987; 326: 156-157
• 17. Havel R.J., Eder H.ABragdon J.H.: The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 1955; 3-4: 1345-1354
• 18. Lowry D.H., Roserbrough N.J., FarrA.L., Randall R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265-275
• 19. Greenlee W.F., Poland A.: An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene, and 2,3,7,8-tetrachloro-dibenzo-p-dioxin. J. Pharmacol. Exp. Ther. 1978; 205: 596-605
• 20. Polcaro C., Nicoletti I., Ossicini L., Caponecchi G., Cozzi R., Fiore M., Palitti F.: Chromatographic and cytogenic analysis of in vivo metabolites of fluoranthene J. Chromatogr. 1988; 448: 127-133
• 21. Weston A., Bowman E.D., Carr P., Rothman N., Strickland P.: Detection of metabolites of polycycklic aromatic hydrocarbons in human urine. Carcinogenesis. 1993; 14: 11053-11055
• 22. Kolin P., Hans M.D., Falk L., Busser R.: Distribution, retention, and elimination of I4C-3,4-benzpyrene after administration to mice abd rats. J. Nat. Cancer Inst. 1959; 23: 541-555
• 23. Yoshikawa T., Ruhr L.P., Flory W., Giamalva D., Church D.F., Pryor W.A.: Toxicity of polycyclic aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 1985: 79: 218-226
• 24. Withey J.R., Law F.C.P., Endrenyi L.: Prercutaneous uptake, distribution, and excretion of pyrene in rats. J. Environ. Health 1993; 40: 601-612
• 25. Santodonato J., Howard P., Basu D.: Health and ecological assesment of polynuclear aromatic hydrocarbons. J. Environ. Path. Toxicol. 1981; 5: 1-364
• 26. Vaessen H.A.M.G., Jekel A.A., Wilbers A.A.M.M.: Dietary intake of polycyclic aromatic hydrocarbons. Toxicol. Environ. Chem. 1988; 16: 281-294
• 27. World Health Organization (WHO). Guidelines for drinking-ater quality. Geneva. 1985; 1: 70-72
• 28. Kobylińska K.: Formy molekularne cytochromu P-450 wątroby szczura. Postępy Biochemii. 1994, 40; 248-252
• 29. Sun, J.D., Wolff, R.K., Kanapilly, G.M.: Deposition, retention, and biological fate of inhaled benzo[a]pyrene adsorbed onto ultrafine particles, and as a pure aerosol. Toxicol. Appl. Pharmacol. 1982; 65: 231-244
• 30. Buckley T.J., Lioy P.J.: An examination of the time course from human dietary exposure to polycyclic aromatic hydrocarbons to urinary elimination of 1-hydroxypyrene. Br. J. Ind. Med. 1992; 49: 113-124
• 31. Lipniak M., Brandys J.: Toxicokinetics of fluoranthene, pyrene and benz(a)anthracene in the rat. Polycyclic Aromatic Compunds. 1993; 3: 111-119
• 32. Lipniak-Gawlik M.: Effect of polycyclic aromatic hydrocarbons on the elimination kinetics of pyrene and the urinary excretion profile of 1-hydroxypyrene in the rat. J. Toxiol Environ. Health. 1998; 55: 503-516
• 33. Boyland E., Sims P.: Metabolism of polycyclic compounds. The metabolism of pyrene in rats and rabbits. Biochem. J. 1964; 90: 391-398
• 34. Bouchard M., Viau G.: Urinary and biliary excretion kinetics of 1-hydroksypyrene following intravenous and oral administration of pyrene in rats. Toxicology. 1998; 127: 69-84
• 35. Willet K.L., Randerath K„ Zhout G-D., Safe S.H.: Inhibition of CYP1A1 -dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Biochem. Pharmacol. 1998; 55: 831-839