Effects of levamisole on pregnancy in ewes

• Autorzy: Pancarci S M , Gungor O. , Gurbulak K. , Cenesiz M. , Kaya M. , Cenesiz S. , Guzeloglu A.
• Języki publikacji: EN

Abstrakty

EN

The effects of levamisole, as an anthelmintic or immunomodulator, on pregnancy were investigated in ewes. Immunomodulatory and anthelmintic doses of levamisole and physiologic saline were injected on days 0 (oestrus), 7, 14, and 21 in group 1 (immunomodulatory dose; n=7), group II (anthelmintic dose; n=6), and group III (control; n=6), respectively. The first service pregnancy rate, tended to be lower (P<0.06) in group I (28.6%) compared to that of groups II (83.3%) and III (83.3%). Plasma progesterone (P₄) concentration was significantly higher (P<0.05) in group II compared to that of group III on day 3, and there was a treatment x day interaction (P<0.05). No effect of levamisole treatments on plasma P₄ concentrations was detected once pregnancy was established. There was a numeric decline in plasma cholesterol concentrations in group II, compared to group I or III on day 3. In conclusion, levamisole as an immunomodulator is detrimental for the establishment of pregnancy, possibly by stimulating general and intrauterine immunity.

Słowa kluczowe

EN

immunomodulatory agent; pregnancy; levamisole effect; veterinary medicine; ewe; immunomodulation; levamisole

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2007
• Tom: 51
• Numer: 2
• Opis fizyczny: p.253-256,fig.,ref.

Twórcy

autor

Pancarci S M

• University of Kafkas, 36100, Kars, Turkey

autor

Gungor O.

autor

Gurbulak K.

autor

Cenesiz M.

autor

Kaya M.

autor

Cenesiz S.

autor

Guzeloglu A.

Bibliografia

• 1. Abeyagunawardena A.S., Dillon M.J., Rees L., van't Hoff W., Trompeter R.S.: The use of steroid-sparing agents in steroid-sensitive nephrotic syndrome. Pediatr Nephrol 2003, 18, 919-924.
• 2. Anderson J. C.: Levamisole and bovine mastitis. Vet Rec 1984, 11, 138-140.
• 3. Atessahin A., Karahan I., Pirincci I.: Effects of therapeutic and toxic doses of levamisole on thyroid hormones and some biochemical parameters in sheep. Cell Biochem Funct 2004, 22, 281-286.
• 4. Barnea E.R.: Insight into early pregnancy events: the emerging role of the embryo. Am J Reprod Immunol 2004, 51, 319-322.
• 5. Bozkurt T., Tanyıldızı S., Türk G.: Effects of levamisole on hyaluronidase activity and sperm characteristics in rams. Theriogenology 2004, 62, 323-329.
• 6. Coles G.C., Giordano D.J., Trischler J.P.: Efficacy of levamisole against immature and mature nematodes in goats with induced infections. Am J Vet Res 1989, 50, 1074-1075.
• 7. Einstein R., Jones R.S., Knifton A., Starmer G.A.: Levamisole. In: Principles of Veterinary Anthelmintics. Longman Scientific & Technical, Longman Group UK Ltd, 1994, pp. 504-505.
• 8. Flesh J., Harel W., Nelken D.: Immunopotentiating effect of levamisole in the prevention of bovine mastitis, fetal death and endometritis. Vet Rec 1982, 17, 56-57.
• 9. Gokce G., Irmak K., Sural E., Uzlu E.: Clinical observations on the antihelmintic and preventive effect of immunomodulators in sheep pox I. The use of levamisole for treatment and prevention in sheep pox. J Fac Vet Med Un Kafkas 1997, 3, 211-215.
• 10. Hafeez F., Ahmed T.M., Samina U.: Levamisole in steroid dependent and frequently relapsing nephrotic syndrome. J Coll Physicians Surg Pak 2006, 16, 35-37.
• 11. Hansen P.J.: Regulation of uterine immune function by progesterone: lessons from the sheep. J Reprod Immunol 1998, 40, 63-79.
• 12. Kazy Z., Puhó E., Czeizel A.E.: Letter to the Editor; Levamisole (Decaris®) treatment during pregnancy. Reprod Toxic 2004, 19, 3.
• 13. Lowe R. J.: Levamisole as an immunostimulant. Vet Rec 1980, 106, 390.
• 14. Ott T.L., Yin J., Wiley A.A., Kim H-T, Gerami-Naini B., Spencer T.E., Bartol F.F., Burghardt R.C., Bazer F.W.: Effects of the estrous cycle and early pregnancy on uterine expression of Mx protein in sheep (Ovis aries). Biol Reprod 1998, 59, 784-794.
• 15. Prakash B.S., Meyer H.H.D., Schallenberger E., Van De Wiel D.F.M.: Development of sensitive enzyme-immunoassay (EIA) for progesterone determination in unextracted bovine plasma using the second antibody technique. J Steroid Biochem 1987, 28, 623-627.
• 16. Roberts R.M., Xie S., Mathialagan N.: Maternal recognition of pregnancy. Biol Reprod. 1996, 54, 294- 302.
• 17. Spector S., Munjal I., Schmidt D.E.: Effects of the immunostimulant, levamisole, on opiate withdrawal and levels of endogenous opiate alkaloids and monoamine neurotransmitters in rat brain. Neuropsychopharmacology 1998, 19, 417-427.
• 18. Tekin S., Hansen P.J.: Natural killer-like cells in the sheep: functional characterization and regulation by pregnancy-associated proteins. Exp Biol Med 2002, 227, 803-811.
• 19. Xu J.J., Qian T.S., Jiang J.J., Chen C.J., Huang Z.C., Wang C.F.: Clinical studies in the use of BCG and levamisole in the treatment of glomerulonephritis. Nephrol Dial Transplant 1991, 6, 548-553.