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2006 | 62 | 07 |

Tytuł artykułu

Dzialanie fitoestrogenow na organizm czlowieka i zwierzat

Warianty tytułu

EN
Influence of phytoestrogens on humans and animals

Języki publikacji

PL

Abstrakty

EN
Phytoestrogens are compounds found in plants with estrogenic activity. Their chemical structure is similar to estradiol. Three main classes of phytoestrogens are: isoflavones, lignans and coumestans. The major bioactive isoflavones are genistein and daidzein. Phytoestrogens are widely present in plants regularly consumed by animals and humans: e.g. oats, barley, wheat, corn, and clover. The most significant sources of isoflavones are soybeans and soy foods. Lignans are present in plant foods: mainly in flaxseed, but also in grains, fruit and vegetables. Phytoestrogens are compounds which exhibit estrogenic activity. This activity was first recognized in sheep and is known as “Clover Disease”. In these animals phytoestrogens cause reproductive disorders or even infertility. The feeding of female rats with a soy rich diet induces an increase in uterine weight. Vaginal modifications have also been observed. Phytoestrogens also exhibit anticarcinogenic activity. Animal studies have demonstrated reduced cancer development with soybean consumption. Genistein and other phytoestrogens have a beneficial role in obesity and diabetes mellitus. These compounds cause slight decreases in insulin, total cholesterol and triglycerides content. Phytoestrogens also increase the amount of cholesterol in high density lipoproteins (HDL) and decrease the amount of VLDL- and LDL-cholesterol, they can reduce risk of cardiovascular diseases. Experiments performed on animals demonstrate that genistein and daidzein clearly inhibit lipogenesis and enhance lipolysis. Phytoestrogens also have a special role in the prevention of osteoporosis.

Wydawca

-

Rocznik

Tom

62

Numer

07

Opis fizyczny

s.736-738,tab.,bibliogr.

Twórcy

autor
  • Akademia Rolnicza, ul.Wolynska 35, 60-637 Poznan
autor

Bibliografia

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  • 14. Kandulska K., Nogowski L., Szkudelski T.: Effect of some phytoestrogens on metabolism of rat adipocytes. Reprod. Nutr. Dev. 1999, 39, 497-501.
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  • 16. Loewe S., Lange F., Spohr E.: Über weibliche Sexualhormone (Thelytropine). Biochem. Zeitschr. 1927, 180, 1-26.
  • 17. Nogowski L., Maækowiak P., Kandulska K., Szkudelski T., Nowak K. W.: Genistein-induced changes in lipid metabolism of ovariectomized rats. Ann. Nutr. Metab. 1998, 42, 360-366.
  • 18. Peterson T. G., Barnes S.: Genistein inhibits both estrogen and growth factor stimulated proliferation of human breast cancer cells. Cell Growth Diff. 1996, 7, 1345-1351.
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  • 23. Setchell K. D. R., Gosselin S. J., Welsh M. B., Johnston J. O., Balistreri W. F.: Dietary estrogens - a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 1987, 93, 225-233.
  • 24. Shutt D. A., Cox R. I.: Steroid and phytoestrogen binding to sheep uterine receptors in vitro. Endocrinology 1972, 52, 299-310.
  • 25. Smith R. M., Tiesinga J. J., Shah N., Smith J. A., Jarett L.: Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin. Arch. Biochem. Biophys. 1993, 300, 238-246.
  • 26. Szkudelska K., Nogowski L., Kaczmarek P., Pruszyńska-Oszmałek E., Szkudelski R., Sieczka A., Szkudelski T.: Hormonal and metabolic effects of genistein and daidzein in male rat. J. Anim. Feed Sci. 2003, 12, 841-849.
  • 27. Szkudelska K., Szkudelski T., Nogowski L.: Daidzein, coumestrol and zearalenone affect lipogenesis and lipolysis in rat adipocytes. Phytomedicine 2002, 9, 338-345.
  • 28. Szkudelski T., Nogowski L., Pruszyńska-Oszmałek E., Kaczmarek P., Szkudelska K.: Genistein restricts leptin secretion from rat adipocytes. J. Steroid. Biochem. Mol. Biol. 2005, 96 (praca w druku).
  • 29. Thiagarajan D. G., Bennink M. R., Bourguin L. D., Kavas F. A.: Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium. Amer. J. Clin. Nutr. 1998, 68, 1394-1399.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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