Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis - the first experience

• Autorzy: Brozmanova M. , Calkovsky V. , Plevkova J. , Tatar M.
• Języki publikacji: EN

Abstrakty

EN

Allergic rhinitis is a common cause of chronic cough. Topical corticosteroids are regarded as the most effective first-time treatment in allergic rhinitis. In this study we evaluated the cough sensitivity during the early and late allergic responses in guinea pigs with experimental allergic rhinitis. Another aim of the study was to follow up the effect of inhaled beclomethasone dipropionate on the cough in guinea pigs with allergic rhinitis. 31 guinea pigs were sensitized with ovalbumin (OA). Animals were intranasally challenged with OA (experiment) or saline (control) in 7-day intervals for 9 weeks. Cough was induced by inhalation of citric acid aerosols in gradually increasing concentrations for 30 s and was evaluated 1 h after the 8th nasal challenge (NCH) and 17 h after the 9th NCH. Cough was significantly increased only during an early allergic response, 1 h after repeated NCH [18 (14-23) vs. 8 (3-10); P<0.001]. Five experimental animals were inhaling aerosol of beclomethasone dipropionate seven days between the 8th and the 9th NCH and cough was evaluated 1 h after the 9th NCH. Inhaled corticosteroids significantly inhibited the enhanced allergic rhinitis related cough [4 (1-9) vs.19 (9-37) vs. 6 (3-9); P<0.05].

Słowa kluczowe

EN

guinea pig; allergic rhinitis; asthma; citric acid; corticosteroid; chronic cough; cough

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2004
• Tom: 55
• Numer: 3
• Opis fizyczny: p.23-30,fig.,ref.

Twórcy

autor

Brozmanova M.

• Comenius University, 26 Sklabinska St., 03753 Martin, Slovakia

autor

Calkovsky V.

autor

Plevkova J.

autor

Tatar M.