Dendrimers: properties and applications

• Autorzy: Klajnert B. , Bryszewska M.
• Języki publikacji: EN

Abstrakty

EN

Dendrimers are a new class of polymeric materials. They are highly branched, mono­disperse macromolecules. The structure of these materials has a great impact on their physical and chemical properties. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The paper gives a con­cise review of dendrimers' physico-chemical properties and their possible use in various areas of research, technology and treatment.

Słowa kluczowe

EN

macromolecule; tetrahydrofuran; dendrimer; polyamidoamine; physical property; chemical property; polymeric material; ethylenediamine; cascade molecule

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 1
• Opis fizyczny: p.199-208,fig.

Twórcy

autor

Klajnert B.

• University of Lodz, St.Banacha 12-16, 90-237 Lodz, Poland

autor

Bryszewska M.

Bibliografia

• 1.Tomalia, D.A., Baker, H., Dewald, J.R., Hall, M., Kallos, G., Martin, S., Roeck, J., Ryder, J. & Smith, P. (1985) A new class of polymers: Starburst- dendritic macromolecules. Polym. J. 17, 117-132.
• 2.Newkome, G.R., Yao, Z.Q., Baker, G.R. & Gupta, V.K. (1985) Cascade molecules: A new approach to micelles, A[27]-arborol. J. Org. Chem. 50, 2003-2006.
• 3.Hodge, P. (1993) Polymer science branches out. Nature 362, 18-19.
• 4.Hawker, C.J. & Frechet, J.M.J. (1990) Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules. J. Am. Chem. Soc. 112, 7638­7647.
• 5.Alper, J. (1991) Rising chemical stars could play many roles. Science251, 1562-1564.
• 6.Tomalia, D.A., Naylor, A.M. & Goddard III, W.A. (1990) Starburst dendrimers: Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angew. Chem., Int. Edn. 29, 138-175.
• 7.Weener, J.-W., van Dongen, J.L.J. & Meijer, E.W. (1999) Electrospray mass spectrometry studies of poly(propylene imine) dendrimers: Probing reactivity in the gas phase. J. Am. Chem. Soc. 121, 10346-10355.
• 8.Caminati, G., Turro, N.J. & Tomalia, D.A. (1990) Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants. J. Am. Chem. Soc. 112, 8515-8522.
• 9.Fischer, M. & Voegtle, F. (1999) Dendrimers: From design to applications - A progress report. Angew. Chem., Int. Edn. 38, 884-905.
• 10.Hawker, C.J. & Frechet, J.M.J. (1992) Unusual macromolecular architectures: The convergent growth approach to dendritic polyesters and novel block copolymers. J. Am. Chem. Soc. 114, 8405-8413.
• 11.Zimmerman, S.C., Zeng, F., Reichert, D.E.C. & Kolotuchin, S.V. (1996) Self-assembling dendrimers. Science, 271, 1095-1098.
• 12.Frechet, J.M.J. (1994) Functional polymers and dendrimers: Reactivity, molecular architecture, and interfacial energy. Science 263, 1710-1715.
• 13.Mourey, T.H., Turner, S.R., Rubenstein, M., Frechet, J.M.J., Hawker, C.J. & Wooley, K.L. (1992) Unique behaviour of dendritic macromolecules: Intrinsic viscosity of polyether dendrimers. Macromolecules 25, 2401-2406.
• 14.Jansen, J.F.G.A., de Brabander van den Berg, E.M.M. & Meijer, E.W. (1994) Encapsulation of guest molecules into a dendritic box. Science 266, 1226-1229.
• 15.Jansen, J.F.G.A. & Meijer, E.W. (1995) The dendritic box: Shape-selective liberation of encapsulated guests. J. Am. Chem. Soc. 117, 4417-4418.
• 16.Archut, A., Azzellini, G.C., Balzani, V., Cola, L.D. & Voegtle, F. (1998) Toward photoswitchable dendritic hosts. Interaction between azobenzene-functionalized dendrimers and eosin. J. Am. Chem. Soc. 120, 12187-12191.
• 17.Gilat, S.L., Adronov, A. & Frechet, J.M.J. (1999) Light harvesting and energy transfer in novel convergently constructed dendrimers. Angew. Chem., Int. Edn. 38, 1422-1427.
• 18.Adronov, A., Gilat, S.L., Frechet, J.M.J., Ohta, K., Neuwahl, F.V.R. & Fleming, G.R. (2000) Light harvesting and energy transfer in laser-dye-labelled poly(aryl ether) dendrimers. J. Am. Chem. Soc. 122, 1175-1185.
• 19.Roberts, J.C., Bhalgat, M.K. & Zera, R.T. (1996) Preliminary biological evaluation of polyaminoamine (PAMAM) StarburstTM dendrimers. J. Biomed. Material Res. 30, 53-65.
• 20.Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J.-W., Meijer, E.W., Paulus, W. & Duncan, R. (2000) Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. J. Controlled Release 65, 133-148.
• 21.Wiener, E.C., Auteri, F.P., Chen, J.W., Brechbiel, M.W., Gansow, O.A., Schneider, D.S., Belford, R.L., Clarkson, R.B. & Lauterbur, P.C. (1996) Molecular dynamics of ion-chelate complexes attached to dendrimers. J. Am. Chem. Soc. 118, 7774-7782.
• 22.Bryant, L.H., Brechbiel, M.W., Wu, C., Bulte, J.W.M., Herynek, V. & Frank, J.A. (1999) Synthesis and relaxometry of high-generation (G=5, 7, 9, and 10) PAMAM dendrimer-DOTA-gadolinium chelates. J. Magn. Reson. Imaging9, 348-352.
• 23.Bourne, M.W., Margerun, L., Hylton, N., Campion, B., Lai, J.J., Derugin, N. & Higgins, C.B. (1996) Evaluation of the effects of intravascular MR contrast media (gadolinium dendrimer) on 3D time of flight magnetic resonance angiography of the body. J. Magn. Reson. Imaging6, 305-310.
• 24.Sigal, G.B., Mammen, M., Dahmann, G. & Whitesides, G.M. (1996) Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by influenza virus: The strong inhibition reflects enhanced binding through cooperative polyvalent interactions. J. Am. Chem. Soc. 118, 3789-3800.
• 25.Roy, R., Zanini, D., Meunier, S.J. & Romanowska, A. (1993) Solid-phase synthesis of dendritic sialoside inhibitors of influenza A virus haemagglutinin. J. Chem. Soc. Chem. Commun. 1869-1872.
• 26.Zanini, D. & Roy, R. (1998) Practical synthesis of Starburst PAMAM alpha-thiosialodendrimers for probing multivalent carbohydrate-lectin binding properties. J. Org. Chem. 63, 3486-3491.
• 27.Twyman, L.J., Beezer, A.E., Esfand, R., Hardy, M.J. & Mitchell, J.C. (1999) The synthesis of water soluble dendrimers, and their application as possible drug delivery systems. Tetrahedron Lett. 40, 1743-1746.
• 28.Liu, M., Kono, K. & Frechet, J.M.J. (2000) Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents. J. Controlled Release 65, 121-131.
• 29.Zhuo, R.X., Du, B. & Lu, Z.R. (1999) In vitro release of 5-fluorouracil with cyclic core dendritic polymer. J. Controlled Release 57, 249-257.
• 30.Hawthorne, M.F. (1993) The role of chemistry in the development of boron neutron capture therapy of cancer. Angew. Chem., Int. Edn. 32, 950-984.
• 31.Barth, R.F., Adams, D.M., Soloway, A.H., Alam, F. & Darby, M.V. (1994) Boronated starburst dendrimer-monoclonal antibody immunoconjugates: Evaluation as a potential delivery system for neutron capture therapy. Bioconjug. Chem. 5, 58-66.
• 32.Liu, L., Barth, R.F., Adams, D.M., Soloway, A.H. & Reisefeld, R.A. (1995) Bispecific antibodies as targeting agents for boron neutron capture therapy of brain tumors. J. Hematotherapy 4, 477-483.
• 33.Capala, J., Barth, R.F., Bendayam, M., Lauzon, M., Adams, D.M., Soloway, A.H., Fenstermaker, R.A. & Carlsson, J. (1996) Boronated epidermal growth factor as a potential targeting agent for boron neutron capture therapy of brain tumors. Bioconjug. Chem. 7, 7-15.
• 34.Bielinska, A.U., Kukowska-Latallo, J.F., Johnson, J., Tomalia, D.A. & Baker, J.R. (1996) Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res. 24, 2176-2182.
• 35.Kukowska-Latallo, J.F., Raczka, E., Quintana, A., Chen, C.L., Rymaszewski, M. & Baker, J.R. (2000) Intravascular and endobronchial DNA delivery to murine lung tissue using a novel, nonviral vector. Hum. Gene Therapy 11, 1385-1395.
• 36.Haensler, J. & Szoka, F.C., Jr. (1993) Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug. Chem. 4, 372-379.
• 37.Tomalia, D.A. & Dvornic, P.R. (1994) What promise for dendrimers? Nature 372, 617-618.
• 38.Knapen, J.W.J., van der Made, A.W., de Wilde, J.C., van Leeuwen, P.W.N.M., Wijkens, P., Grove, D.M. & van Koten, G. (1994) Homogenous catalysts based on silane dendrimers functionalized with arylnickel(II) complexes. Nature 372, 659-663.
• 39.Cooper, A.I., Londono, J.D., Wignall, G., McClain, J.B., Samulski, E.T., Lin, J.S., Dobrynin, A., Rubinstein, M., Burke, A.L.C., Frechet, J.M.J. & DeSimone, J.M. (1997) Extraction of a hydrophilic compound from water into liquid CO2 using dendritic surfactants. Nature 389, 368-371.