Cellular aspects of folate and antifolate membrane transport

• Autorzy: Brzezinska A. , Winska P. , Balinska M.
• Języki publikacji: EN

Abstrakty

EN

Folates one carbon carriers take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.

Słowa kluczowe

EN

transport system; neoplastic cell; amino acid; normal cell; thymidylate; antifolate; chemotherapy; metabolism; membrane transport; folate; transport activity; cancer development; folate receptor; purine

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 3
• Opis fizyczny: p.735-749,fig.

Twórcy

autor

Brzezinska A.

• Polish Academy of Sciences, L.Pasteura 3, 02-093 Warsaw, Poland

autor

Winska P.

autor

Balinska M.

Bibliografia

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