The assessment of DNA damage in lymphocytes of wooden furniture workers

• Autorzy: Palus J. , Dziubaltowska E. , Rydzynski K.
• Języki publikacji: EN

Abstrakty

EN

Single-strand breaks (SSB) and DNA repair were detected in peripheral lymphocytes derived from workers of a furniture factory in a non-polluted region of Poland. The workers were exposed to wood dust (n = 19), or to the dust and varnishes or lacquers together (n = 5). Four groups were studied simultaneously: (a) exposed workers smokers of cigarettes (n = 14), (b) nonexposed smokers - control (n = 14), (c) exposed workers' nonsmokers (n = 14), (d) exposed nonsmokers (n = 10). In exposed workers DNA SSB and DNA repair were statistically significantly increased. DNA SSB was clearly higher in the smoking workers than in the smoking controls. Cigarette smoking itself has produced no evident increase in the frequency of DNA SSB in the control group. Occupational exposure had a significant effect on DNA repair in non stimulated lymphocytes both in smoking and nonsmoking workers.

Słowa kluczowe

EN

tobacco smoking; DNA break; lymphocyte; human lymphocyte; DNA repair; adenocarcinoma; worker; cancer; peripheral lymphocyte; single strand break

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 2
• Opis fizyczny: p.605-610,fig.

Twórcy

autor

Palus J.

• Nofer Institute of Occupational Medicine, Teresy 8, P.O. Box 199, 90-950 Lodz, Poland

autor

Dziubaltowska E.

autor

Rydzynski K.

Bibliografia

• Balarajan, R. & McDowall, M.E. (1988) Br. J. Ind. Med. 45, 438-486.
• Benigni, R., Calcagnile, M., Fabri, G., Giuliani, A., Leopardi, P., & Paoletti, A. (1984) Mutation Res. 138, 105-111.
• Celotti, L., Biasin, R., Ferraro, P. & Fiorentino, M.(1990) MutaL Res. 245, 217-222.
• Cesarone, C.F., Bolognesi, C. & Santi, L. (1979) Anal Biochem. 100, 188-197.
• Freeman, S.E. & Ryan, L. (1988) Mutation Res. 194, 143-150.
• IARC (1995) Monographs on the evaluation of car­cinogenic risks to humans. Vol. 62., Lyon.
• Imlay, J.A. & Linn, S. (1988) Sdence 240, 1302-1309.
• Hogstedt, L.C. (1988) IARC Sci. Publ. 89, 265-270.
• Kurttio, P., Kalliokoski, P., Lampelo S. & Jan- tunen, M.J. (1990) Mutation Res. 242, 9-15.
• Kurttio, P., Norppa, H., Jarventaus, H., Sorsa, M. & Kalliokoski, P. (1993) Scand. J. Work Envi­ron. Health 19. 132-134.
• Sanderson, P., Wennerberg, K. & Tagesson, Ch. (1994) Carcinogenesis 15, 137-139.
• Maciejewska, A., Wojtczak, J., Bielichowska- Cybula, G., Domanska, A., Dutkiewicz, J. & Molocznik, A. (1993) Occup. Med. 44,277-288 (in Polish).
• Mello-Filho, A.C. & Meneghini, R. (1984) Biochim. Biophys. Acta 781, 56-63.
• Mohtashamipur, E. & Norpoth, K. (1990) Toxicol Lett. 51, 277-285.
• Nelson, E., Zhou, Z., Carmichael, P.L., Norpoth, K. & Fu, J. (1993) Arch. Toxicol 67, 586-589.
• Oesch, F., Hengstler, J.G. & Fucks, J. (1994) Muta­tion Res. 321, 175-185.
• Reitz, M., Coen, R. & Lanz, E. (1994) Environ. Res. 65, 12-21.
• Schmezer, P., Kuchenmeister, F., Klein, R.G., Pool-Zobel, R.G., Fengel, B.L., Stehlin, D. & Wolf, J. (1994) Arbeitsmed. Sozialmed. Umwelt- med. 21, 13-17.
• Selikoff, I.J., Hammond, E.C. & Churg, J. (1968) J. Am. Med. Assoc. 204, 104-110.
• World Health Organization (1989) Biennial Re­port 1988-1989; pp. 16-17, International Agency for Research on Cancer, Lyon.