Budowa i rola DBP [Vitamin D-Binding Protein] w stanach fizjologii i patologii u zwierzat i ludzi

• Autorzy: Madej J P , Boratynski J. , Nowacki W.

Warianty tytułu

EN

Structure and role of DBP [Vitamin D-Binding Protein] on physiological and pathological states in animals and humans

• Języki publikacji: PL

Abstrakty

EN

The vitamin D-binding protein (DBP), also known as group-specific component or Gc globulin, demonstrates a pleiotropic effect in human and animal bodies. DBP binds vitamin D and its derivatives. It plays a key role in the extracellular actin-scavenger system (EASS) through the ability of actin binding. DBP is a precursor of the macrophage-activating factor in the inflammation-primed macrophage activation cascade. It binds various cells to the surface of and can significantly enhance the leukocyte chemotactic activity for C5a and C5a des Arg. Anti-human DBP serum shows a cross-reactivity with the serum of the various species in double immunodiffusion or immunoelectrophoresis tests. The polymorphism of DBP in humans and animals indicates a species-characteristic pattern in PAGE and IEF. Gc globulin may be used as a non-specific marker of diseases and some clinical states of patients.

Słowa kluczowe

PL

fizjologia zwierzat; bialko DBP zob.bialko wiazace witamine D; bialko wiazace witamine D; fizjologia czlowieka; patologia; funkcje biologiczne; budowa

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 09
• Opis fizyczny: s.987-991,rys.,tab.,bibliogr.

Twórcy

autor

Madej J P

• Akademia Rolnicza, ul.Norwida 31, 50-375 Wroclaw

autor

Boratynski J.

autor

Nowacki W.

Bibliografia

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