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Tytuł artykułu

Ocena in vitro grzybow z rodzaju Aspergillus i Penicillium na nowe leki przeciwgrzybicze

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Języki publikacji

PL

Abstrakty

EN
Fifty four mould strains (32 Aspergillus and 22 Penicillium) isolated from clinical materials were tested using dilution method. Two test media were used: Yeast Nitrogen Base (YNB) and Czapek Dox (CD). The following drugs were tested: amorolfine, cyclopirox, itraconazole, and terbinafine. In the dilution method, the drugs were tested at four contrentrations: 0.1 mg/l, 1 mg/l, 10 mg/l, and 100 mg/l. No matter which medium and/or drug was used, terbinafine turned out to be most effective. The drug at a conceatration of 1 mg/l inhibited 88.9% of the strains in the CD medium. The MIC values in the YNB medium varied from 0,1 mg/l through 100 mg/1, however, 50% of the strains were inhibited at 1 mg/l or less. Itraconazole revealed a fairly good in vitro antifungal action, particularly in the CD medium: 77.8% of the strains were inhibited at 10 mg/l or less. Aspergillus fumigatus and Aspergillus flavus were most susceptible to itraconazole. The MIC values of cyclopirox amounted to 100 mg/l for all of the strains in the CD medium but not in the YNB where they varied from 1 mg/l to 100 mg/l. Amorolfine was the least effective drug. Most of the strains were inhibited at a concentration of at least 100 mg/l. The findings give evidence that the susceptibility of Aspergillus and Penicillium to the particular drugs is different, and that the results are influenced by the test medium.

Wydawca

-

Rocznik

Tom

46

Numer

1

Opis fizyczny

s.157-162,tab.,bibliogr.

Twórcy

autor
  • Uniwersytet Jagiellonski, Czysta 18, 31-121 Krakow
autor
autor

Bibliografia

  • ARMSTKONG D, 1993. Treatment ofopportunistic fungal infections. Clin. Jnfect. Dis. 16: 1-9.
  • CLEARLY J. P., TAYLOR J. W., CHAPMAN S. W. 1992. Itraconazole in antifungal therapy. Ann. Pharmacother 26: 502-509.
  • GRAYBILL J. R. 1992. Future directions of antifungal chemoterapy. Clin. Jnfect. Dis. 14, suppl. 1: S170-S181.
  • LYMAN C., WALSH T. J. 1992. Systemically administered antifungal agents: a review of clinical pharmacology and therapeutic applications. Drug. 44: 9-35.
  • MACURA A. B. 1991. Fungal resistance to antimycotic drugs. A growing problem. Inter. J. Dermat. 30: 181-183.
  • MACURA A. B. PAWLIK B. 1997. Fungal susceptibility to amorolfine. Mikol. Lek. 4: 85-87.
  • MUHLDORFER S. M., KONIG H. J. 1990. Prophylaxis of fungal infections with itraconazole in immunocompromised cancer patients. Mycoses. 33: 291-295.
  • PAWLIK B., MACURA A. B. 1997. The susceptibility of fungi from lesion isolates to terbinafine. Mikol. Lek. 4: 11-14.
  • RINGEL S. M. 1996. New antifungal agents for the systemie mycoses. Mycopathologia 109: 75-87.
  • VARTHALITIS L, MEUNIER F. 1995. Invasive fungal infections in cancer patients. Prophylaxis of fungal infections. Bailliere's Clinical Infections Diseases 2: 157-177.

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Bibliografia

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