The constituents of hepatic and placental mixed function oxidase [MFO] systems after acute carbon tetrachloride intoxication

• Autorzy: Bienioszek M. , Plewka A. , Chmielarska-Kotus K. , Pajak J.
• Języki publikacji: EN

Abstrakty

EN

The influence of acute carbon tetrachloride intoxication on hepatic and placental cytochrome P-450 content, and on NADPH-cytochrome P-450 reductase was examined in Wistar female rats. The animals were pretreated with a single dose of CC14 before pregnancy. The contents of the constituents of the MFO system were measured at term. The results revealed that the CCl4-mediated decrease at the total hepatic cytochrome P-450 level was reduced by pregnancy. Carbon tetrachloride pretreatment did not change the placental cytochrome P-450 level. A significant increase in placental microsomal cytochrome P-450 reductase activity was found after acute CC14 intoxication, which did not influence this enzyme in the liver of pregnant individuals.

Słowa kluczowe

EN

cytochrome; placental cytochrome; carbon; acute intoxication; enzyme; mixed function oxidase; tetrachloride; hepatic cytochrome; intoxication; liver; placenta; acute carbon intoxication

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1995
• Tom: 04
• Numer: 2
• Opis fizyczny: p.13-16,fig.

Twórcy

autor

Bienioszek M.

• Silesian School of Medicine, 42-752 Katowice-Ligota, Poland

autor

Plewka A.

autor

Chmielarska-Kotus K.

autor

Pajak J.