Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats

• Autorzy: Pires W. , Wanner S.P. , La Guardia R.B. , Rodrigues L.O.C. , Silveira S.A. , Coimbra C.C. , Marubayashi U. , Lima N.R.V.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (Ttail), core temperature and blood pressure were measured after injection of 2 µL of 5 x 10-3 M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, Ttail was measured using a thermistor taped to the tail and intraperitoneal temperature (Tb) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 ± 4 mmHg Phy vs. 121 ± 3 mmHg Sal; P < 0.001) and higher Ttail (26.4 ± 1.0° C Phy vs. 23.8 ± 0.5° C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in Tb compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure.

Słowa kluczowe

EN

central cholinergic synapse; heat loos; thermoregulation; rat; running; arterial pressure; blood pressure

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2007
• Tom: 58
• Numer: 1
• Opis fizyczny: p.3-17,fig.,ref.

Twórcy

autor

Pires W.

• Federal University of Minas Gerais, Av. Antonio Carlos, 6627, 31270-901. Belo Horizonte, Minas Gerais, Brazil

autor

Wanner S.P.

autor

La Guardia R.B.

autor

Rodrigues L.O.C.

autor

Silveira S.A.

autor

Coimbra C.C.

autor

Marubayashi U.

autor

Lima N.R.V.