3D domain swapping, protein oligomerization, and amyloid formation

• Autorzy: Jaskolski M.
• Języki publikacji: EN

Abstrakty

EN

In 3D domain swapping, first described by Eisenberg, a structural element of a monomeric protein is replaced by the same element from another subunit. This pro­cess requires partial unfolding of the closed monomers that is then followed by adhe­sion and reconstruction of the original fold but from elements contributed by different subunits. If the interactions are reciprocal, a closed-ended dimer will be formed, but the same phenomenon has been suggested as a mechanism for the formation of open-ended polymers as well, such as those believed to exist in amyloid fibrils. There has been a rapid progress in the study of 3D domain swapping. Oligomers higher than dimers have been found, the monomer-dimer equilibrium could be controlled by mu­tations in the hinge element of the chain, a single protein has been shown to form more than one domain-swapped structure, and recently, the possibility of simulta­neous exchange of two structural domains by a single molecule has been demon­strated. This last discovery has an important bearing on the possibility that 3D do­main swapping might be indeed an amyloidogenic mechanism. Along the same lines is the discovery that a protein of proven amyloidogenic properties, human cystatin C, is capable of 3D domain swapping that leads to oligomerization. The structure of domain- swapped human cystatin C dimers explains why a naturally occurring mutant of this protein has a much higher propensity for aggregation, and also suggests how this same mechanism of 3D domain swapping could lead to an open-ended polymer that would be consistent with the cross-β structure, which is believed to be at the heart of the molecular architecture of amyloid fibrils.

Słowa kluczowe

EN

amyloid formation; amyloid fibril; conformational disease; protein; bovine spongiform encephalopathy; protein aggregation; amyloidosis; 3D domain swapping

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.807-827,fig.

Twórcy

autor

Jaskolski M.

• A.Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland

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