Wplyw glodzenia na dystrybucje sulfamerazyny podawanej dozylnie u owiec

• Autorzy: Garwacki S , Karlik W. , Rutkowski J. , Wiechetek M.
• Języki publikacji: PL

Abstrakty

EN

The experiments were carried out on 8 mature ewes fed ad libitum or being on starvation diet. Sulfamerazine was administered at a dose of 60 mg per 1 kg of body weight intravenously. During starvation the biological half-life of sulfamerazine in the blood plasma was prolonged (not significantly). The results of sulphonamide determinations in the rumen contents of sheep showed that a significant amount of the drug administered intravenously penetrated to the forestomachs and its amount was much higher in the rumen contents of starved sheep than in those fed ad libitum; beginning from the 10th hour after sulfamerazine administration its level was much higher in the rumen contents than in the blood plasma. On the basis of the results one can claim that sulfamerazine concentration in the forestomachs is depending not so much on its increased inflow into the forestomachs as on a decreased outflow related with the pH value of the forestomach contents. Due tо a high level of sulphamides in the forestomachs of starved ruminants the rate of their elimination from the body can be diminished.

Słowa kluczowe

PL

farmakokinetyka; sulfonamidy; sulfamerazyna; owce

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 1993
• Tom: 49
• Numer: 05
• Opis fizyczny: s.221-223,rys.,tab.,bibliogr.

Twórcy

autor

Garwacki S

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Nowoursynowska 166, 02-766 Warszawa

autor

Karlik W.

autor

Rutkowski J.

autor

Wiechetek M.

Bibliografia

• 1. Atef M., Salem A. A., Al-Samarrae S. A., Zafer S. A.: Zbl. Vet. Med. A. 28, 113, 1981.
• 2. Austin F. H.: Fed. Proc. 26, 1001, 1967.
• 3. Bratton A. C., Marshall E. K.: J. Biol. Chem. 128, 537, 1939.
• 4. De Backer P., Belpaire F. M., Bogaert M. G., Debackere M.: Am. J. Vet. Res. 43, 1744, 1982.
• 5. Garwacki S., Hornik H., Karlik W., Dąbrowski J.: Acta Vet. Scand. Supp. 87, 145, 1991.
• 6. Heinze W., Losch K., Schlüter H., Nattermann Н., Böttcher С.: Mh. Vet.-Med. 39, 746, 1984.
• 7. Jenkins W. L., Davis L. E., Boulos В. M.: Am. J. Vet. Res. 36, 1771, 1975.
• 8. Losch K., Heinze W., Mieth K., Lender S.: Arch. exper. Vet. med., Leipzig, 34, 451, 1980.
• 9. Nesic P., Ibrovic M.: Berl. Münch. tierärztl. Wschr. 73, 403, 1963.
• 10. Nielsen P., Romvary A., Rasmussen F.: J. Vet. Pharmacol. Therap. 1, 37, 1978.
• 11. Pashov D., Droumev D., Koychev V., Dimitrova D., Dyakov L., Zhelyaskova Z., Vulchanova R., Daskalova O.: Acta Vet. Scand. Supp. 87, 147, 1991.
• 12. Van Gogh H., Van Miert A. S. J. P. A. M.: Zbl. Vet. Med. A, 24, 503, 1977.