The effect of chemo- and chemoimmunotherapy on the presence of circulating melanoma cells in peripheral blood. Preliminary results

• Autorzy: Szenajch J. , Kozak A. , Kruszewski A.A. , Babiej E. , Chomicka M. , Struzyna J. , Wiktor-Jedrzejczak W.
• Języki publikacji: EN

Abstrakty

EN

Reverse transcription and polymerase chain reaction (RT/PCR) with primers specific for tyrosinase allow for a new method of early detection of individual melanoma cells in peripheral blood. Using this test the effect of chemo- and chemoimmunotherapy on the spread of early micrometastatic cancer cells has been evaluated. No significant correlations have been found between RT/PCR results on the one hand and stage of disease, a kind of the therapy protocol used and usage of the therapy as an adjuvant or palliative on the other hand. Thus, although the RT/PCR test for detection of circulating individual melanoma cells might help in identification of minimal residual disease in some patients, it has no application for routine staging of more advanced disease and in monitoring the response to therapy.

Słowa kluczowe

EN

chemotherapy; cancer cell; tyrosinase; reverse transcription; melanoma cell; chemoimmunotherapy; polymerase chain reaction; malignant melanoma

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 1
• Opis fizyczny: p.95-102,fig.

Twórcy

autor

Szenajch J.

• Military School of Medicine, Szaserow 128, 00-909 Warsaw, Poland

autor

Kozak A.

autor

Kruszewski A.A.

autor

Babiej E.

autor

Chomicka M.

autor

Struzyna J.

autor

Wiktor-Jedrzejczak W.

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