Enhanced food and water intake in renin transgenic rats

• Autorzy: Szczepanska-Sadowska E. , Paczwa P. , Dobruch J.
• Języki publikacji: EN

Abstrakty

EN

In short term experiments angiotensin II (Ang II) is a potent stimulant of thirst, however it is not known whether prolonged activation of the renin-angiotensin system is associated with chronic alteration of water or food intake. Renin transgenic rats TGRmRen(2)27 (TGR) exhibit significant elevation of AngII in the brain regions involved in regulation of body fluid balance. The purpose of the present study was to find out whether TGR rats manifest also different water (WI) and food (FI) intake and renal excretory functions in comparison to their parent Sprague Dawley (SD) strain. To this end 24h WI and FI as well as urine excretion (Vu) and urinary outputs of solutes (Cosm), sodium (UNaV) and potassium (UKV) were compared under baseline conditions in 16 TGR and 15 SD rats having free access to water and food. In 15 TGR and 17 SD rats effect of 24h dehydration on water intake was investigated. Under baseline conditions TGR rats consumed significantly greater amount of food and water than SD rats. Vu, UNaV and UKV were not significantly different in both strains. Cumulative water intakes in SD and TGR rats subjected to 24h dehydration did not differ. The results reveal that under baseline conditions TGR rats manifest greater food and water intakes than SD rats whereas stimulation of thirst by water deprivation is similar in both strains. The results suggest that the ingestive behavior may be chronically altered by upregulation of the renin-angiotensin system.

Słowa kluczowe

EN

water intake; renin; hypertension; food intake; transgenic animal; renin-angiotensin system; thirst; rat; angiotensin II

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2003
• Tom: 54
• Numer: 1
• Opis fizyczny: p.81-88,fig.

Twórcy

autor

Szczepanska-Sadowska E.

• Medical University of Warsaw, Krakowskie Przedmiescie 26-28 str., 00-927 Warsaw, Poland

autor

Paczwa P.

autor

Dobruch J.