EN
The article is a review of the results of investigations concerning digestive enzymes of warble flies (Hypoderma lineatum, H. bovis), called hypodermines. Special attention was paid to their antigenic, immungenic and immunosuppressing properties and the relation of these features with enzymatic properties. It was proved that the elimination of the enzymatic activity of hypodermines may increase their immunogenicity, which opend opportunities for creating more effective vaccines against hypodermosis.