Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warszawa, Poland
Bibliografia
1. Goldman, I.D. (1977) Effects of methotrexate on cellular metabolism: Some critical elements in drug-cell interaction. Cancer Treat. Rep. 61,549 - 558.
2. Bertino, J R. (1979) Toward improved selectivity in cancer chemotherapy. Cancer Res. 39, 293 - 304.
3. Schomagel, J. & McVie, J.G. (1983) The clinical pharmacology of methotrexate. Cancer Treat. Rev. 10,53 - 75.
4. Jolivet, J., Cowan, K.H., Curt, G.A, Clendeninn, N.J St Chabner, B.A. (1983) The pharmacology and clinical use of methotrexate. N. Engl. J. Med. 292,1094-1104.
5. Sirotnak, F.M. & DeGraw, J.I. (1984) Selective antitumor activity of folate analogs; in Folate antagonists as therapeutic agents (Sirotnak, F.M., Burchall, J.J., Ensminger, W.B. & Montgomery, J.A., eds.) vol. 2, pp. 43 - 93, Academic Press, Orlando, Florida.
6. Baliriska, M., Galivan, J. & Coward, J.K. (1981) Efflux of methotrexate and its polyglutamates from hepatic cells in vitro. Cancer Res. 41,2751 - 2756.
7. Allegra, C.J., Drake, J.C., Jolivet, J. & Chabner, B.A. (1985) Inhibition of phosphoribo7ylamino- imidazolcarboxyimide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proc. Natl. Acad. Sci. U.S.A. 82, 4881 -4885.
8. Allegra, C.J., Chabner, B.A, Drake, J.C., Lutz, R., Rodbard, D. & Jolivet, J. (1985) Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J. Biol. Chem. 260,9720 - 9726.
9. Allegra,C.J., Huang, K., Yeh, G.C., Drake,J.C. & Baram, J. (1987) Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J. Biol. Chem. 262,13520 -13526.
10. Greco, W.R. & Hakala, M.T. (1980) Biochemical pharmacology of lipophilic diaaminopyrimi- dine antifolates in mouse and human cells in vitro. Mot. Pharmacol. 18,521 - 528.
11. Werbel, L. (1984) Design and synthesis of lipophilic antifols as cancer agents; in Folate antagonists as therapeutic agents (Sirotnak, F.M., Burchall, J.J., Ensminger, W.B. & Montgomery, J.A., eds.) vol. 1, pp. 261 - 290, Academic Press, Orlando, Florida.
12. Jones, T.R., Calvert, A.J., Jackman, A.L., Brown, S.J. & Harrap, K.R. (1981) A potent antitumor quinazoline inhibitor of thymidylate synthase: synthesis, biological properties and therapeutic results in mice. Eur. /. Cancer 17,11 -19.
13. Jackson, R.C., Jackman, A.L. & Calvert, A H. (1983) Biochemical effects of quinazoline inhibitor of thymidylate synthase, N-(4(N-((2- amino-4-hydroxy-6-<]uinazolinyl)methyl)prop- 2-ynylamino)benzoyl)-L-glutamic acid (CB37- 17) on human lymphoblastoid cells. Biochem. Pharmacol. 24, 3783 - 3790.
14. Sikora, E., Jackman, A.L., Newell, D.R. & Calvert, A.H. (1988) Formation and retention and biological activity of NlO-propargy 1-5,8- -dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro. Biochem. Pharmacol. 37,4047 -4054.
15. Pawełczak, K., Jones, T.R., Kempny, M., Jackman, A.L., Newell, D.R., Krzyżanowski, L. & Rzeszotarska, B. (1988) Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-y-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition. J. Med. Chem. 32,160 -165.
16. Pa til, S.D., Jones, C., Nair, M.G., Galivan, J., Malcy, F., Kisliuk, R., Gaumont, Y., Throndike, J., Duch, D. & Ferrone, R. (1989) Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propa- rgyl-5,8-dideazafolic acid and related compounds. /. Med. Chem. 32,1284 - 1289.
17. Taylor, E.C., Harrington, P.J., Flechter, S R., Beardsley, G.P. & Moran, R.G. (1985) Synthesis of antileukemic agents 5,10-dideazaaminopte- rin and 5,10-dideaza-5,6,7,8-tetrahydrofolami- nopterin. J. Med. Chem. 28,914 - 921.
19. Beardsley, G.P., Moroson, B.A., Taylor, E.C. & Moran, R.G. (1988) A new folate antimetabolite 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine biosynthesis. /. Biol. Chem. 264,328 - 333.
20. Kisliuk, R.L. (1986) The metabolism of pteroylpolyglutamates; in Chemistry and Biology of Pteridines (Cooper, B.A., Whitehead, V.M., eds.) pp. 743 - 756, W. de Gruyter, Berlin.
21. Throndike, J., Gaumont, Y., Powers, J., Kisliuk, R.L. & Piper, J.R. (1988) Synergistic growth inhibition of human lymphoma cells by combination of trimetrexate with 5,10-dideaza- tetrahydrofolate. Proc. Amer. Assoc. Cancer Res. 29,1134.
22. Galivan, J., Rhee, M.S., Johnson, T.B., Dilwith, R., Nair, M.G., Bunni, M. & Priest, D.G. (1989) The n»le of cellular folates in enhancement of activity of thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase. /. Biol. Chem. 264,10685 -10692.
23. Throndike, J., Gaumont, Y., Kisliuk, R.L., Sirotnak, F.M., Murthy, B.R., Nair, M.G. & Piper, J.R. (1989) Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cells extracts. Cancer Res. 49,158 -163.
24. Galivan, J., Nimec, Z. & Rhee, M. (1987) Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dide- azafolate with methotrexate and the lipophilic antifolates trimetrexate or metoprin. Cancer Res. 47,5256-5260.
25. Galivan, J., Nimec, Z., Rhee, M., Boschelii, D., Oronsky, A.L. & Kerwar, S.S. (1988) Antifolate drug interactions. Enhancement of growth inhibition due to the antipurine 5,10-dideazate- trahydrofolic acid by lipophylic dihydrofolate reductase inhibitors metoprin and trimetrexate. Cancer Res. 48,2421 - 2425.
26. Rhee, M.S., Balińska, M., Bunni,M.,Priest,D.G., Maley, G.F., Maley, F. & Gali van, J. (1990) Role of substrate depletion in the inhibition of thymidylate biosynthesis by dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells. Cancer Res. 50,3979 - 3984.
27. Balińska, M., Rhee, M., Whiteley, J.M., Priest, D.G. & Galivan, J. (1991) Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate. Arch. Biochem. Biophys. 284,291 - 222.
28. Baram, J., Chabner, B. A., Drake, J.C., Fitzburgh, A.L., Sholar, P.W. & Allegra, C.J. (1988) Identification of biochemical properties of 10-formyl- dihydrofolate, a novel folate found in methotrexate-trcated cells. J. Biol. Chem. 263, 7105-7111.
29. Seither, R.L., Trent, D.F., Mikulecky, D.C., Rape, T.J. & Goldman, I.D. (1989) Folate-pool interconversions and inhibition of biosynthetic processes after exposure of LI 210 leukemia cells to antifolates. /. Biol. Chem. 264,17016 - 17023.
30. Gaumont, Y., Kisliuk, R.L., Parsons, J.C. & Greco, W.R. (1992) Quantitation of folic acid enhancement of antifolate synergism. Cancer Res. 52,2228 - 2235.
31. Gaumont, Y., Kisliuk, R. L., Emkey, R., Piper,J.R. & Nair, M.G. (1989) Folate enhancement of antifolate synergism in human lymphoma cells; in Chemistry and Biology of Pteridines (Curtius, H.C., Blau, N. & Ghisla, S., eds.) pp. 1132 -1136, W. de Gruyter, Berlin.
32. Fergusson, K., Boschelli, D., Hoffman, P., Oronsky, A., Whiteley, J.M., Webber, S., Galivan, J., Freisheim, J., Hynes, J. & Kerwar, S.S. (1990) Synergy between 5,10-dideaza-5,6,7,8- -tetrahydrofolic acid and methotrexate in mice bearing LI210 tumor. Cancer Chemother. Pharmacol. 25,173 - 176.