The aging corotid body

• Autorzy: Pokorski M. , Walski M. , Dymecka A. , Marczak M.
• Języki publikacji: EN

Abstrakty

EN

The respiratory system is subject to the aging process, which could limit its responsiveness to hyperventilatory stimuli. Attenuation of the ventilatory response to hypoxia in old age is, as yet, an unresolved issue. Such attenuation may be germane for the pathogenesis of respiratory disorders developing more often in elderly subjects. The aim of this study was to determine the potential adverse effects of age on the morphology and function of carotid bodies. Morphology was studied at the level of electron microscopy on carotid bodies dissected from adult young (3 months) and old (>2 years) rats and function by comparing the hypoxic ventilatory response in populations of young (mean age 24 years) and old (mean age 71 years) female subjects. The human protocol consisted of a progressive hypoxia test, based on a rebreathing technique in a closed system. The hypoxic ventilatory response was evaluated from the slopes of minute ventilation on arterial oxygen saturation. The results of the morphological study showed degenerative changes developing with age in the ultrastructure of carotid bodies. On the other side, respiratory responses to hypoxia in old women were well preserved and were no less than those in young women. Therefore, a discrepancy appeared between the morphological and functional aspects. These findings suggest development of compensatory mechanisms in brain respiratory areas which maintain primary defensive reflexes, such as the hyperventilation of hypoxia.

Słowa kluczowe

EN

respiratory disorder; ultrastructure; ventilatory hypoxic response; pathogenesis; ventilatory response; carotid body; aging; respiratory system; hypoxia

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2004
• Tom: 55
• Numer: 3
• Opis fizyczny: p.107-113,fig.,ref.

Twórcy

autor

Pokorski M.

• Polish Academy of Sciences, 5 Pawinskiego St., 02-106 Warsaw, Poland

autor

Walski M.

autor

Dymecka A.

autor

Marczak M.