Badania ultrastrukturalne wplywu fluoru na watrobe szczura

• Autorzy: Dabrowska E.
• Języki publikacji: PL

Abstrakty

PL

Celem pracy była ocena wpływu fluorku sodu (NaF) na obraz ultrastrukturalny wątroby szczura. Zmiany w obrazie dotyczyły w większości jąder komórkowych, mitochondriów, siateczki endoplazmatycznej szorstkiej.

EN

The aim of the study was to evaluate the effect of fluorine on the ultrastructural picture of rat liver hepatocytes. Wistar rats received aqueous NaF solution at two concentrations: 10.6 mg NaF/L and 32.0 mg NaF/L. The animals were exposed to NaF since their intrauterine life till maturity. The rat liver was examined in the 14th, 30th, 60lh and 90th day of the fluorine-exposed life and on the 30th day after the exposure had been ceased. The ultrastructural examination procedure comprised collecting four 1 mm3 sections of the anterior lobe from each of 75 rats. Normal preparation procedures were used. The resultant preparations were examined on a OPTON 900 PC Scanning Electron Microscope. The analysis of the ultrastructural pictures of rat liver hepatocytes indicates that ultrastructural changes in the hepatocytes become intensified with increased fluorine dose. This refers to the nuclei, mitochondria, rough and smooth cytoplasmic reticulum and sinusoids. Most of these changes are reversible.

Słowa kluczowe

PL

prochnica zebow; szczury; zwierzeta laboratoryjne; fluorek sodu; jadro komorkowe; profilaktyka; ultrastruktura; watroba; mitochondria; zywienie czlowieka

EN

dental caries; rat; laboratory animal; sodium fluoride; cell nucleus; prophylaxis; ultrastructure; liver; mitochondrion; human nutrition

• Wydawca: -
• Czasopismo: Bromatologia i Chemia Toksykologiczna
• Rocznik: 2001
• Tom: 34
• Numer: 4
• Opis fizyczny: s.305-310,rys.,bibliogr.

Twórcy

autor

Dabrowska E.

• Akademia Medyczna, ul.M.Sklodowskiej-Curie 24a, 15-276 Bialystok