Intramolecular signalling in immunoglobulins - new evidence emerging from the use of supramolecular protein ligands

• Autorzy: Piekarska B. , Konieczny L. , Rybarska J. , Stopa B. , Spolnik P. , Roterman I. , Krol M.
• Języki publikacji: EN

Abstrakty

EN

The postulated intramolecular signaling in immunoglobulins generated by antigen binding has been controversial for years. The high heterogeneity of immune complexes as signaling systems and the requirement of the immobilized antigen form for efficient triggering of effector activity is likely the reason for the lack of clarity. Here we present new evidence supporting the notion of intramolecular signaling, based on the use of supramolecular dyes that bind to signal-derived specific sites in immunoglobulins.

Słowa kluczowe

EN

immunoglobulin; immune complex; Congo red; intramolecular signalling; antibody

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 3
• Opis fizyczny: p.487-501,fig.,ref.

Twórcy

autor

Piekarska B.

• Jagiellonian University, Medical College, Kopernika 7, 31-034 Krakow, Poland

autor

Konieczny L.

autor

Rybarska J.

autor

Stopa B.

autor

Spolnik P.

autor

Roterman I.

autor

Krol M.