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2006 | 15 | 2 |

Tytuł artykułu

A note on frequency of A1 and A2 variants of bovine beta-casein locus in Polish Holstein bulls

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Besides its nutritional value, bovine beta-casein is a source of bioactive peptides called betacasomorphins produced during digestion of raw or processed milk. It was shown that the betacasomorphin 7 originates only from beta-casein variants A1 or B and may be a significant risk factor in human ischemic heart disease, arteriosclerosis, type I diabetes and sudden infant death syndrome. In this study, the frequency of the A1 allele in a sample of Polish Holstein bulls commonly used in artificial insemination (A. I. bulls) was analysed and the potential for production of milk capable of releasing undesirable beta-casomorphin 7 is discussed. Among 143 A. I. bulls, three genotypes were identified (A1/A1, A2/A2, A1/A2) resulting in frequencies of 0.402 and 0.598, for A1 and A2, respectively. Although, the clinical implications of A1 milk on human health is still under discussion it may be necessary to monitor reproductive bulls and decrease the frequency of allele A1.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

15

Numer

2

Opis fizyczny

p.195-198,fig.,ref.

Twórcy

autor
  • University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-718 Olsztyn, Poland
autor

Bibliografia

  • Elliot R.B., Harris D. P., Hill J.P., Bibby N. J., Wasmuth H.E., 1999. Type I (insulin dependent) diabetes mellitus and cow milk: casein variant consumption. Diabetologia 42, 292-296
  • Hartwig A., Teschemacher H., Lehmann W., Gauly M., Erhardt G., 1997. Influence of genetic polymorphisms in bovine milk on the occurrence of bioactive peptides. In: Milk Protein Polymorphism. International Dairy Federation. Proceedings of the IDF Seminar, Palmerston (New Zealand), pp. 459-460
  • Jarmolowska B., Kostyra E., Krawczuk S., Kostyra H., 1999. Beta-casomorphin-7 isolated from Brie cheese. J. Sci. Food Agr. 79, 1788-1792
  • Laugesen M., Elliott R., 2003. Ischaemic heart disease, type 1 diabetes, and cow milk A1 betacasein. N.Z. Med. J. 116, 1-19
  • Lien S., Alestrom P., Hungland H., Rogne S., 1992. Detection of multiple beta-casein (CASB) alleles by amplification created restriction sites (ACRS). Anim. Genet. 23, 333-338
  • McLachlan C.N.S., 2001. Beta-casein A1, ischaemic heart disease mortality, and other illnesses. Med. Hypotheses 56, 262-272
  • Roginsky H., 2003. Encyclopedia of Dairy Sciences. Academic Press, London
  • Sun Z., Zhang Z., Wang X., Cade R., Elmer Z., Fregly M., 2003. Relation of beta-casomorphin to apnea in sudden infant death syndrome. Peptides 24, 937-943
  • Tailford K.A., Brry C.L., Thomas A.C., Campbell J.H., 2003. A casein variant in cow’s milk is atherogenic. Atherosclerosis 170, 13-19
  • Thorsdottir I., Birgisdottir B.E., Johannsdottir I.M., Harris D.P., Hill J., Steingrimsdottir L., Thorsson A.V., 2000. Different (beta-casein) fractions in Icelandic versus Scandinavian cow’s milk may influence diabetogenicity of cow’s milk in infancy and explain low incidence of insulindependent diabetes mellitus in Iceland. Pediatrics 106, 719-724
  • Truswell A.S., 2005. The A2 milk case: a critical review. Eur. J. Clin. Nutr. 59, 623-631

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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