Azurocidin - inactive serine proteinase homolog acting as a multifunctional inflammatory mediator

• Autorzy: Watorek W.
• Języki publikacji: EN

Abstrakty

EN

Azurocidin, also known as cationic antimicrobial protein 37 kDa (CAP37) or hepa­rin-binding protein (HBP) is an inactive homolog of serine proteinases residing in granulocytes. The ability to cleave peptide bond was lost due to replacement of two of the three residues from the conserved catalytic triad characteristic for serine protein- ases. Azurocidin has a broad spectrum of antimicrobial activity, mainly against Gram-negative bacteria. It is also recognized as a multifunctional inflammatory medi­ator for its contracting effects on endothelial cells causing an increase of vascular per­meability, capacity to bind endotoxin and ability to attract monocytes to inflammation sites.

Słowa kluczowe

EN

cationic antibacterial protein; prohormone; infection; tissue damage; proenzyme; trypsin-like serine proteinase; physiological process; azurocidin; heparin-binding protein

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2003
• Tom: 50
• Numer: 3
• Opis fizyczny: p.743-752,fig.

Twórcy

autor

Watorek W.

• Wroclaw University, Tamka 2, 50-137 Wroclaw, Poland

Bibliografia

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