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Czasopismo

2004 | 63 | 2 |

Tytuł artykułu

Exercise-induced apoptosis in the renal tubular cells of the rat

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
A number of studies have shown that acute physical exercise is associated with the induction of apoptosis not only in skeletal muscle but also in many distant organs. One of the pathogenic agents responsible for exercise-induced damage in many tissues is the generation of oxygen free radicals. The aim of the present study was to examine the influence of exercise-induced oxidative stress on the rat kidney. The analysis was performed on the kidneys of rats subjected to treadmill running until exhaustion. Our results demonstrated that acute exercise led to apoptotic damage of the renal distal tubular cells, although this was not a result of oxidative stress.

Słowa kluczowe

Wydawca

-

Czasopismo

Rocznik

Tom

63

Numer

2

Opis fizyczny

p.213-216,fig.,ref.

Twórcy

  • Medical University, Chalubinskiego 6a, 50-368 Wroclaw, Poland
autor
autor
autor
autor

Bibliografia

  • 1. Arslan S, Erdem S, Kilinc K, Sivri A, Tan E, Hascelik Z (2001) Free radical changes in rat muscle tissue after exercise. Rheumatol Int, 20: 109–112.
  • 2. Azenabor AA, Hoffman-Goetz L (1999) Intrathymic and intrasplenic oxidative stress mediates thymocyte and splenocyte damage in acutely exercised mice. J Appl Physiol, 86 (6): 1823–1827.
  • 3. Dziegiel P, Podhorska-Okolow M, Surowiak P, Ciesielska U, Rabczynski J, Zabel M (2003) Influence of exogenous melatonin on doxorubicin-evoked effects in myocardium and in transplantable Morris hepatoma in rats. In Vivo, 17: 325–328.
  • 4. Lieberthal W, Levine JS (1996) Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury. Am J Physiol Renal Physiol, 271: F477–F488.
  • 5. Liu J, Yeo HC, Overvik-Douki E, Hagen T, Doniger ST, Chu DW, Brooks GA, Ames BN (2000) Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J Appl Physiol, 89: 21–28.
  • 6. Oberbauer R, Schwarz C, Regele HM, Hansmann C, Meyer TW, Meyer G (2001) Regulation of renal tubular cell apoptosis and proliferation after ischemic injury to a solitary kidney. J Lab Clin Med, 138 (5): 343–351.
  • 7. Phaneuf S, Leeuwenburgh C (2000) Apoptosis and exercise. Med Sci Sports Exerc, 33 (3): 393–396.
  • 8. Podhorska-Okolow M, Sandri M, Zampieri S, Brun B, Rossini K, Carraro U (1998) Apoptosis of myofibers and satellite cells: exercise-induced damage in skeletal muscle of the mouse. Neuropathol Appl Neurobiol, 24: 518–531.
  • 9. Sekhon CS, Sekhon BK, Singh I, Orak JK, Singh AK (2003) Attenuation of renal ischemia/reperfusion injury by a triple drug combination therapy. J Nephrol, 16: 63–74.
  • 10. Steller H (1995) Mechanisms and genes of cellular suicide. Science, 267: 1456–1462.

Typ dokumentu

Bibliografia

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