Hordeina zawarta w karmie jako srodek dopingujacy dla koni

• Autorzy: Kania B F , Majcher A. , Kowalska M.
• Języki publikacji: PL

Abstrakty

EN

This paper reviews the sources, identification and pharmacokinetics of hordenine. This biogenic amine is generated during the breakdown of tyramine beginning on the first day of barley germination. It is contained in Cacti as well as in different kinds of reeds (arundinacea, canaris, and aquatica) including a variety of species cultivated in Poland (such as Motyčka, Nakielska, and Puławska) which contain substantial quantities of hordenine. Horse Racing Organisations in some countries consider this chemical compound to be a stimulant, yet in fact, hordenine from natural food stuffs contained in feed can reach a concentration of up to 18-90 pg/ml in urea and up to 1 pg/ml in serum. The pharmacological profile of hordenine shows that its stimulatory action on the respiratory and cardiovascular systems is short-lived and appears only when a high dose of the compound is used. Because the effects are limited in time, the compound does not alter psychomotor activity in horses. It seems that hordenine is not a stimulant in the strict sense of the word. No data is available showing its stimulatory effect on isolated limbs or on muscle activity. Horses which were given 1 kg barley per day (hordenine content ~ 0,05% d.m.) could receive approximately 500 mg hordenine (~ 1 mg/kg B.W.).

Słowa kluczowe

PL

wlasciwosci chemiczne; wystepowanie; wlasciwosci biologiczne; farmakokinetyka; hordeina; budowa; toksycznosc; konie; srodki dopingujace

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2000
• Tom: 56
• Numer: 04
• Opis fizyczny: s.214-217,bibliogr.

Twórcy

autor

Kania B F

• Szkola Glowna Gospodarstwa Wiejskiego, ul. Nowoursynowska 166, 02-787 Warszawa

autor

Majcher A.

autor

Kowalska M.

Bibliografia

• 1. Bouřek C. A., Carrigan M. J., Seaman J. T, Evers J. V: Delayed development of clinical signs in sheep affected by Phalaris aquatica staggers. Aust. Vet. J. 1987, 64, 31.
• 2.Bourke C. A., Carrigan M. J., Dixon R. J.: The pathogenesis of the nervous syndrome of Phalaris aquatica toxicity in sheep. Aust. Vet. J. 1990, 67, 356.
• 3. Bourke C. A., Carrigan M. J.: Mechanisms underlying Phalaris aquatica „sudden death” syndrome in sheep. Aust. Vet. J. 1992, 69, 165.
• 4. Cheeke P. R.: Endogenous toxins and mycotoxins in forage grasses and their effects on livestock. J. Anim. Sci. 1995, 73, 909.
• 5. Cheeke P. R.: Natural Toxicants in Feeds. Forages and Poisonous Plants. Interstate Publishers, Inc., Danville, Illinois, U.S.A., 1998, s. 275-278, 310- -311, 389-390.
• 6.Duynisweld G. W., Wittenberg К. M. : Evaluation of Rival, Venture and Frontier reed canarygrass as pasture forage. Can. J. Anim. Sci. 1993, 73, 89.
• 7. Forbes T. D. A., Carpenter B. B., Randel R. D., Tolleson D. R.: Effects of phenolic monoamines on release of luteinizing hormone and on plasma ad- renotropic hormone, norepinephrine, and cortisol concentrations in wethers. J. Anim. Sci. 1994, 72, 464.
• 8. Forbes T. D. A., Pemberton I. J., Smith G. R., Hensarling С. M: Seasonal variation of two phenolic amines in Acacia berlandieri. J. Arid. Environ. 1995, 30, 403.
• 9. Frank M, Weckman T. J., Woods W. E., Tai C. L., Chang S. L., Ewing A., Blake J. W, Tobin T.: Hordenine: pharmacology, pharmacokinetics and be- chavioural effects in the horse. Equine Vet. J. 1990, 22, 437.
• 10.Hapke H. J.. Strathmann W.: Pharmacological effects of hordenine. Dt. tierarztl. Wschr. 1995, 102, 228.
• 11. Howe R. C, Ranieri R. L., Statz D., Mc Laughlin J. L.: Cactus alkaloids. XXXIV. Hordenine HC1 from Coryphantha vivipara var. arizonica. Planta Medica 1977, 31, 294.
• 12.Irvine C. H. G.: Responses of horses to hordenine and related substances. Proc. 7th Int. Conf. Racing Anal. Vet. Louisville, KY, 1988, s. 47-50.
• 13. Kirshna R. B., Dancis J., Levitz M: Influence of organic cations on basic amino-acid uptake by human placental villi. Reprod. Fertility, 1995, 7, 149.
• 14. Markham K. R., Geiger H., Jaggy H.: Kaempterol - 3-o-glucosyl (l-2)rham- noside from Ginkgo biloba and a reappraisal of other gluco (1-2, 1-3 and 1-4) rhamnoside structures. Phytochemistry 1992, 31, 1009.
• 15. Marten G. C„ Jordan R. M., Howin A. W: Biological significance of reed canargrass alkaloids and associated palability variation to grazing sheep and cattle. Agron. J. 1976, 68, 909.
• 16. Marten G. C„ Jordan R. M, Howin A. W: Improved lamb performance asso­ciated with breeding form alkaloid reduction in reed canarygrass. Crop. Sci. 1981, 21, 295.
• 17. McKenna D. J., Towers G. H. N.: Biochemistry and pharmacology of trypta- mines and beta-carbolines. A mini review. Psychoact. Drugs 1984, 16, 347.
• 18. Neal J. M., Sato P. T, Johnson C. L., McLaughlin J. L.: Cactus alkaloids. X. Isolation of hordenine and N-methyltyramine from Ariocarpus katschoubey- anus. J. Pharmac. Sci. 1971, 60, 477.
• 19. Pemberton I. J., Smith G. R., Forbes T. D. A., Hensarling С. M.: Technical note: an improved method for extraction and quantification of toxic phene- thylamines from Acacia berlandieri. J. Anim. Sci. 1993, 71, 467.
• 20. Ranieri R. L., McLaughlin J. L.: Cactus alkaloids. XXXI. beta-Phenylethy- lamines and tetrahydroisoquinolines from the Mexican cactus dolichothele uberiformis. Lloydia 1977, 40, 173.
• 21 .Rao G. S.: Identity of peyoactin, an antibiotic from peyote (Lophophora wil- liamssi), and hordenine. Pharmacology 1970, 22, 544.
• 22.Schubert B., Fallings P. I., Jogansson M., Ryttman A., Bondensson U:. Hordenine -N, N-dimethyltyramine - studies of occurrence in animal feeds, disposition and responses to exercice in the horse. Proc. 7th Int. Conf. Racing Anal. Vet., Louisville, KY, U.S.A., 1988, s. 51-64.
• 23.Schubert B., Fallings P. L, Bondensson U.: Bordeline substances. Proc. 8th Int. Conf. Racing Anal. Vet., Harare, 1990, s. 197-200.
• 24. Ungemach F. R.: Dopingkontrolle bei Rennpferden. Tierarztl. Prax. 1985, 13, 35.
• 25. Vera-Avila H. R., Forbes T. D. A., Randel R. D.: Plant phenoilc amines: Potential effects on sympathoadrenal medullary, hypothalamic pituitary-adrenal, and hypothalamic-pituitary gonadal function in ruminants. Dom. Anim. Endocrinol. 1996, 13, 285.
• 26. West L. G., Johnson I. T, McLaughlin J. L.: Hordenine for Polyporous ber- kleyi. Lloydia 1974, 37, 633.
• 27 .Wittenbetg К. M., Duynisveld G. W., Tosi H. R.: Comparison of alkaloid content and nutritive value for tryptamine - and /?-carboline-free cultivars of reed canary-grass (Phalaris arundinacea). Can. J. Anim. Sci. 1992, 72, 903.