The experiment involved Wistar rats given orally trace daily doses of selenium-75 for four weeks. The distribution of selenium-75 was evaluated in the carcass and selected organs within 28 days after the last administration. The results were compared with those reported in the literature; the kinetic data provided evidence that the absorption and distribution of selenium depend on several factors involving dosage and the route and period of administration.
1. Bopp B.A., Sonders R.C., Kesterson J.W.: Metabolic fate of selected selenium compounds in laboratory animals and man. Drug Met. Rev., 1982, 13, 271-318
2. Ewan R.C., Pope A.L., Baumann C.A.: Elimination of fixed selenium by the rat. J. Nutr., 1967, 91, 547-554.
3. Grosicki A., Kossakowski S.: Distribution and the whole-body retention of selenium in rats treated repeatedly with inorganic mercury. Bull. Vet. Inst. Pulawy, 1992, 37, 42-47.
4. Grosicki A., Kowalski B., Rachubik J.: Absorption and distribution of inorganic mercury in rats fed a copper-supplemented diet. Bull. vet. Inst. Pulawy, 1997, 41, 149-156.
5. McConnell K.P.: Distribution and excretion studies in the rat after a single subtoxic subcutaneous injection of sodium selenate containing radioselenium. J. Biol. Chem., 1941, 141, 427-437.
6. McKinney J. Metals bioavailability and disposition kinetics research needs workshop. Toxicol. Env. Chem., 1993, 38, 68-71.
7. Shamberger R. Biochemistry of selenium. Ed. E. Frieden. Plenum Press, London 1983.
8. Styblo M., Kalouskova J., Klas J.: Comparison of the kinetics of a trace and a sublethal dose of selenite in rats with particular attention being given to blood selenium distribution. J. Trace Elem. Electrolytes Health Dis., 1991, 5, 155-16.