Selected blood serum biochemical indicators in twelve inbred strains of laboratory mice

• Autorzy: Wirth-Dzieciolowska E , Karaszewska J. , Sadowski T. , Pysniak K. , Gajewska M.

Warianty tytułu

PL

Biochemiczne wskazniki surowicy krwi myszy dwunastu szczepow wsobnych

• Języki publikacji: EN

Abstrakty

EN

A total of 215 animals of twelve inbred strains of mice (A.CA/W, AKR/W, BALB/cW, BN/aW,C57BL/6W, C57Bl/10W, CBA/W, CBAT6/W, C3H/W, DBA/2W, 129Sl/SvW and HLB/219J) bred at the Cancer Centre and Institute of Oncology, Warsaw (Oncology Centre), were characterized In terms of five blood serum biochemical indicators related to their health, reproduction and genetic background. Glucose, total protein, creatinine, triglycerides (triacylglycerols) and total cholesterol were determined in mice aged four months. Significant interstrain differences were found among nearly all parameters considered, with the exception of total protein. The level of triglycerides showed wide interstrain differences and revealed a similar variation trend as the total cholesterol.For cholesterol and triglycerides, significant differences between sexes for the majority of strains were found. The results obtained may be important in the selection of experimental animals,for analysis of changes associated with various diseases, and for the explanation of their genetic background.

PL

Wsobne szczepy myszy hodowane w Centrum Onkologii dostarczane są do wielu instytucji naukowych w kraju. Zwierzęta te scharakteryzowane są pod względem zdrowotnym i reprodukcyjnym oraz mają opracowany profil genetyczny. Obecna praca charakteryzuje poziom glukozy, cholesterolu,kreatyniny, trójglicerydów i białka całkowitego w surowicy krwi. Wykazano istotne różnice pod względem rozpatrywanych parametrów (z wyjątkiem białka całkowitego) między myszami poszczególnych szczepów. Największe różnice stwierdzono w poziomie cholesterolu i trójglicerydów między szczepami oraz między płciami w obrębie szczepów.

Słowa kluczowe

EN

blood indicator; biochemical indicator; blood serum; mouse; mice; inbred strain; laboratory animal

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2009
• Tom: 27
• Numer: 2
• Opis fizyczny: p.159-167,ref.

Twórcy

autor

Wirth-Dzieciolowska E

• The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology in Warsaw, Roentgena 5, 02-781 Warsaw, Poland

autor

Karaszewska J.

autor

Sadowski T.

autor

Pysniak K.

autor

Gajewska M.

Bibliografia

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