The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells

• Autorzy: Galanty A , Michalik M. , Sedek L. , Podolak I.
• Języki publikacji: EN

Abstrakty

EN

We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both cell types in a time-and dose-dependent manner, and proved cytotoxic against cancer cells at significantly lower concentrations than for fibroblasts. LTS-4 also affected the morphology of the examined cells, causing vacuolisation and actin cytoskeleton disintegration, and had an inhibitory effect on the tumour cell motility.

Słowa kluczowe

EN

triterpene saponoside; cytotoxicity; Lysimachia thyrsiflora; melanoma; fibroblast; secondary metabolite; triterpenoid saponin

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2008
• Tom: 13
• Numer: 4
• Opis fizyczny: p.585-598,fig.,ref.

Twórcy

autor

Galanty A

• Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland

autor

Michalik M.

autor

Sedek L.

autor

Podolak I.

Bibliografia

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