Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I

• Autorzy: Zubrzak P. , Kociolek K. , Smoluch M. , Silberring J. , Kowalski M.L. , Szkudlinska B. , Zabrocki J.
• Języki publikacji: EN

Abstrakty

EN

Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2 -Pro3 , Pro3 -Pro4 and Val6 -Pro7 replaced by their tetrazole analogues Ile2-Ψ[CN4]-Ala3 , Pro3 -Ψ[CN4]-Ala4 and Val6 -Ψ[CN4]-Ala7 were synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).

Słowa kluczowe

EN

hymenistatin I; cis-amide bond; cyclosporin A; immunosuppressant; transplanted organ; 1,5-disubstituted tetrazole ring; transplantation; survival

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1151-1154,fig.

Twórcy

autor

Zubrzak P.

• Technical University of Lodz, 90-543 Lodz, Poland

autor

Kociolek K.

autor

Smoluch M.

autor

Silberring J.

autor

Kowalski M.L.

autor

Szkudlinska B.

autor

Zabrocki J.

Bibliografia

• 1.Ellis, G. & West, G.B. (1988) Prog. Med. Chem. 25, 1-33.
• 2.Sigal, N.H. & Dumont, F.J. (1992) Annu. Rev. Immunol. 10, 519-560.
• 3.Petit,G.R., Clewlow, P.J., Defresne, C., Doubeck, D.L., Cerny, R.L. & Rutzler, K. (1990) Can. J. Chem. 68, 708-711.
• 4.Cebrat,M., Wieczorek, Z. & Siemion, I.Z. (1996) Peptides 17, 191-196.
• 5.Konat,R.K., Mierke, D.F., Kessler, H., Kutscher, B., Bernd, M. & Voegeli, R. (1993) Helv. Chim. Acta 76, 1649-1666.
• 6.Marshall,G.R., Humblet, C., Van Opdenbosch, N. & Zabrocki, J. (1981) in: Peptides: Synthesis, Structure and Function, Proc. 7th Am. Pept. Symp. (Rich, D. & Gross, E., eds.) pp. 669-672, Pierce Chemical Co., Rockford IL.
• 7.Yu,K.-L. & Johnson, R.L. (1987) J. Org. Chem. 52, 2051-2059.
• 8.Zabrocki,J., Smith, G. D., Dunbar, J.B., Jr., Iijima, H. & Marshall, G.R. (1988) J. Am. Chem. Soc. 110, 5875-5880.
• 9.Zabrocki,J., Dunbar, J.B., Jr., Marshall, K.W., Toth, M.V. & Marshall, G.R. (1992) J. Org Chem. 57, 202-209.
• 10.Smith, G.D., Zabrocki, J., Flak, T.A. & Marshall, G.R. (1991) Int. J. Pept. Protein Res. 37, 191-197.