Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells

• Autorzy: Kania J. , Baranska A. , Guzdek A.
• Języki publikacji: EN

Abstrakty

EN

In the retinoic acid-differentiated neuroblastoma SH-SY5Y cells, IL-1 induced bind­ing activity of NFkB and up-regulated the expression and activity of MnSOD. The IL-1-elicited effects were partly reversed by IL-4 and IL-6. It is proposed that IL-4 and IL-6 may participate in the regulation of the imbalanced oxidant status induced by IL-1 in differentiated neuroblastoma cells. In the SH-SY5Y cell line, TNFa neither ac­tivated NFkB nor induced MnSOD expression and activity, but was capable of modu­lating the IL-1 effects. Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFkB acti­vation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor kB.

Słowa kluczowe

EN

pyrrolidine dithiocarbamate; cytokine; oxidative stress; retinoic acid; SH-SY5Y cell; neuroblastoma; manganese superoxide dismutase

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2003
• Tom: 50
• Numer: 3
• Opis fizyczny: p.659-666,fig.

Twórcy

autor

Kania J.

• Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland

autor

Baranska A.

autor

Guzdek A.

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